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Ethics of Research on Stem Cells and Regenerative Medicine: Ethical Guidelines in the Islamic Republic of Iran Publisher Pubmed



Afshar L1 ; Aghayan HR2 ; Sadighi J3 ; Arjmand B2 ; Hashemi SM4 ; Basiri M5 ; Samani RO6 ; Ashtiani MK7 ; Azin SA8 ; Hajizadehsaffar E9 ; Gooshki ES10 ; Hamidieh AA11 ; Rezania Moallem MR6 ; Azin SM6 Show All Authors
Authors
  1. Afshar L1
  2. Aghayan HR2
  3. Sadighi J3
  4. Arjmand B2
  5. Hashemi SM4
  6. Basiri M5
  7. Samani RO6
  8. Ashtiani MK7
  9. Azin SA8
  10. Hajizadehsaffar E9
  11. Gooshki ES10
  12. Hamidieh AA11
  13. Rezania Moallem MR6
  14. Azin SM6
  15. Shariatinasab S6
  16. Soleymanigoloujeh M5
  17. Baharvand H5, 12
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Ethics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Health Promotion, Health Metrics Research Center, Institute for Health Sciences Research, ACECR, Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Banihashem Sq., Banihashem St., Ressalat highway, 1665659911, Tehran, Iran
  6. 6. Department of Medical Ethics and Law, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
  7. 7. Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
  8. 8. Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
  9. 9. Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
  10. 10. Medical Ethics and History of Medicine Research Center, Department of Medical Ethics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Pediatric Cell Therapy Research Center, Tehran University of Medical Sciences, Tehran, Iran
  12. 12. Department of Developmental Biology, University of Science and Culture, Tehran, Iran

Source: Stem Cell Research and Therapy Published:2020


Abstract

Background: Regenerative medicine plays a major role in biomedicine, and given the ever-expanding boundaries of this knowledge, numerous ethical considerations have been raised. Main text: Rapid advancement of regenerative medicine science and technology in Iran, emerged the Iranian National Committee for Ethics in Biomedical Research to develop a comprehensive national ethical guideline. Therefore, the present ethical guideline which comprises eleven chapters was developed in 2019 and approved in early 2020. The titles of these chapters were selected based on the ethical considerations of various aspects of the field of regenerative medicine: (1) ethical principles of research on stem cells and regenerative medicine; (2) ethical considerations for research on stem cells (embryonic stem cells, epiblast stem cells, tissue-specific stem cells, stem cells derived from transdifferentiation, induced pluripotent stem cells [iPSCs], germline pluripotent stem cells, germline stem cells, and somatic cell nuclear transfer [SCNT] stem cells); (3) ethical considerations for research on somatic cells in regenerative medicine (adult somatic cells, fetal tissue somatic cells, and somatic cells derived from pregnancy products [other than fetus]); (4) ethical considerations for research on gametes in regenerative medicine; (5) ethical considerations for research related to genetic manipulation (human and animal) in regenerative medicine; (6) ethical considerations for research on tissue engineering in regenerative medicine; (7) ethical considerations for pre-clinical studies in regenerative medicine; (8) ethical considerations for clinical trials in regenerative medicine; (9) ethical considerations for stem cells and regenerative medicine bio-banks; (10) ethical considerations for privacy and confidentiality; and (11) ethical considerations for obtaining informed consent. Conclusion: This article discusses the process of developing the present ethical guidelines and its practical points. We hope that it can play an important worldwide role in advancing ethics of research on stem cells and regenerative medicine. © 2020 The Author(s).