Invesigation of Drd2 and Htr2a Mrna Expression in Two Therapeutic States of Antipsychotic Polypharmacy and Aripiprazole Monotherapy in the Peripheral Blood of Patients With Schizophrenia

Invesigation of Drd2 and Htr2a Mrna Expression in Two Therapeutic States of Antipsychotic Polypharmacy and Aripiprazole Monotherapy in the Peripheral Blood of Patients With Schizophrenia Publisher

Mirabzadeh A^{1, 2} ; Iranpour HR³ ; Khorshid HRK⁴ ; Zareabdollahi D⁴ ; Norouzi M¹ ; Vatankhah V²

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1. Social Determinants of Health Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
2. Imam Khomeini Hospital Complex of Firuzkuh, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran
4. Genetics Research Center, niversity of Social Welfare and Rehabilitation Sciences, Tehran, Iran

Source: Iranian Rehabilitation Journal Published:2020

Abstract

Objectives: Schizophrenia is a severe psychiatric disorder that has profound efects on both individuals and the community. Notwithsanding the suggesion for treating schizophrenia with a minimum dose of drugs, antipsychotic polypharmacy increases the patient’s care coss and drug interactions. Aripiprazole reduces the metabolic side efects of antipsychotic polypharmacy treatment. DRD2 and HTR2A can serve as predictors for response to treatment in schizophrenic patients. The purpose of this survey was to measure the DRD2 and HTR2A genes expression in the peripheral blood samples using Real-Time Quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR). Methods: A total of 19 patients with a long hisory of schizophrenia who received at leas two types of antipsychotics with daily doses of more than 500 mg of chlorpromazine were entered into the sudy. The response rates to the treatment based on scores in the Brief Psychiatric Rating Scale (BPRS) quesionnaire and DRD2 and HTR2A expression were compared between antipsychotic polypharmacy satus and 6 months after monotherapy with aripiprazole. Results: The levels of DRD2 expression decreased signifcantly after the intervention. The mean changes in HTR2A expression and the BPRS quesionnaire and also the relationship between changes in DRD2 and HTR2A expression and changes in BPRS score after the intervention were not signifcant. Discussion: The conversion of the antipsychotic polypharmacy sate to monotherapy with aripiprazole has been accompanied by a signifcant decrease in DRD2A expression. These genes can be used for evaluating the response rate of schizophrenia treatments in the future. © 2020, Iranian Rehabilitation Journal. All Rights Reserved

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Style	Citing Format
MLA	Mirabzadeh A, et al.. "Invesigation of Drd2 and Htr2a Mrna Expression in Two Therapeutic States of Antipsychotic Polypharmacy and Aripiprazole Monotherapy in the Peripheral Blood of Patients With Schizophrenia." Iranian Rehabilitation Journal, vol. 18, no. 3, 2020, pp. 293-300.
APA	Mirabzadeh A, Iranpour HR, Khorshid HRK, Zareabdollahi D, Norouzi M, Vatankhah V (2020). Invesigation of Drd2 and Htr2a Mrna Expression in Two Therapeutic States of Antipsychotic Polypharmacy and Aripiprazole Monotherapy in the Peripheral Blood of Patients With Schizophrenia. Iranian Rehabilitation Journal, 18(3), 293-300.
Chicago	Mirabzadeh A, Iranpour HR, Khorshid HRK, Zareabdollahi D, Norouzi M, Vatankhah V. "Invesigation of Drd2 and Htr2a Mrna Expression in Two Therapeutic States of Antipsychotic Polypharmacy and Aripiprazole Monotherapy in the Peripheral Blood of Patients With Schizophrenia." Iranian Rehabilitation Journal 18, no. 3 (2020): 293-300.
Harvard	Mirabzadeh A et al. (2020) 'Invesigation of Drd2 and Htr2a Mrna Expression in Two Therapeutic States of Antipsychotic Polypharmacy and Aripiprazole Monotherapy in the Peripheral Blood of Patients With Schizophrenia', Iranian Rehabilitation Journal, 18(3), pp. 293-300.
Vancouver	Mirabzadeh A, Iranpour HR, Khorshid HRK, Zareabdollahi D, Norouzi M, Vatankhah V. Invesigation of Drd2 and Htr2a Mrna Expression in Two Therapeutic States of Antipsychotic Polypharmacy and Aripiprazole Monotherapy in the Peripheral Blood of Patients With Schizophrenia. Iranian Rehabilitation Journal. 2020;18(3):293-300.
BibTex	@article{ author = {Mirabzadeh A and Iranpour HR and Khorshid HRK and Zareabdollahi D and Norouzi M and Vatankhah V}, title = {Invesigation of Drd2 and Htr2a Mrna Expression in Two Therapeutic States of Antipsychotic Polypharmacy and Aripiprazole Monotherapy in the Peripheral Blood of Patients With Schizophrenia}, journal = {Iranian Rehabilitation Journal}, volume = {18}, number = {3}, pages = {293-300}, year = {2020} }
RIS	TY - JOUR AU - Mirabzadeh A AU - Iranpour HR AU - Khorshid HRK AU - Zareabdollahi D AU - Norouzi M AU - Vatankhah V TI - Invesigation of Drd2 and Htr2a Mrna Expression in Two Therapeutic States of Antipsychotic Polypharmacy and Aripiprazole Monotherapy in the Peripheral Blood of Patients With Schizophrenia JO - Iranian Rehabilitation Journal VL - 18 IS - 3 SP - 293 EP - 300 PY - 2020 ER -

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