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Comparison Between Intratympanic Injection of Dexamethasone and Methylprednisolone in Idiopathic Sudden Sensorineural Hearing Loss: A Randomized Clinical Trial Publisher



Eftekharian K1, 2 ; Najafi E1 ; Amizadeh M3 ; Mokari N1 ; Faramarzi M4 ; Izadparast Y5 ; Jabbari Moghadam Y6 ; Eftekharian A1, 7
Authors
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Authors Affiliations
  1. 1. Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Stanford University, United States
  3. 3. Department of Otorhinolaryngology, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Department of Otolaryngology, Tehran University of Medical Sciences, Iran
  6. 6. Department of Otorhinolaryngology, School of Medicine, Sina Medical Research and Training Hospital, Children Medical Research and Training Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Otolaryngology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Laryngoscope Investigative Otolaryngology Published:2024


Abstract

Objective: To compare the hearing outcomes of patients with idiopathic sudden sensorineural hearing loss after intratympanic (IT) injection of methylprednisolone and dexamethasone. Study design: Randomized case-controlled clinical trial. Methods: Seventy-five patients diagnosed with idiopathic sensorineural hearing loss were randomly divided into two groups based on therapy. Both groups received oral prednisolone (10 mg/kg; maximum of 60 mg) for 10 days without tapering and received IT injections two times a week for 2 weeks (four injections in total). One group received an IT injection of a 40 mg/mL solution of methylprednisolone, and the other one, 4 mg/mL dexamethasone. Three comparisons between the initial and third-month hearing tests were made to assess the degree of hearing change: (1) pure tone improvement in each individual tone (0.5, 1, 2, 3, and 4 kHz); (2) word-recognition score improvement; and (3) complete, partial, and no recovery of hearing calculated (as defined by American Academy of Otolaryngology-Head and Neck Surgery Clinical Practice Guidelines). Results: The study was completed with 69 of the 75 patients—34 in the methylprednisolone group and 35 in the dexamethasone group. The groups' differences in frequency-specific hearing improvement were not statistically significant. There was no statistically significant difference in the word recognition score improvement between the two groups. Additionally, there was no discernible difference between the two groups' hearing recovery rates. Conclusion: Methylprednisolone and dexamethasone IT injection therapy had similar hearing outcomes. Level of evidence: 2. © 2024 The Author(s). Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.
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