The Interaction Between Rs 3,807,992 Genotypes With the Dietary Inflammatory Index on Leptin, Leptin Resistance, and Galectin 3 in Obese and Overweight Women

The Interaction Between Rs 3,807,992 Genotypes With the Dietary Inflammatory Index on Leptin, Leptin Resistance, and Galectin 3 in Obese and Overweight Women Publisher Pubmed

Shiraseb F¹ ; Farazi M¹ ; Rasaei N¹ ; Clark CCT² ; Jamili S³ ; Mirzaei K^{1, 4}

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1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O.Box: 14155-6117, Tehran, Iran
2. Centre for Intelligent Healthcare, Coventry University, Coventry, CV1 5FB, United Kingdom
3. General Surgeon (Fellowship of Minimally Invasive Surgery), Department of Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: BMC Endocrine Disorders Published:2022

Abstract

Objective: Obesity is related to increasing leptin and some inflammatory factors that are associated with low-grade inflammation. Moreover, several studies have shown Caveolin-1 (CAV1) genetic variations may be associated with dietary intake. The current study aimed to evaluate the interaction of CAV1 rs3807992 with types of the energy-adjusted dietary inflammatory index (EDII) in leptin, leptin resistance, and Galectin 3, as inflammatory factors. Methods: This cross-sectional study was carried out on 363 overweight and obese females. Dietary intake and DII were obtained from a 147-item food frequency questionnaire (FFQ). The CAV-1 genotype was measured using the PCR-RFLP method. Anthropometric values and serum levels of leptin and Galectin 3 were measured by standard methods. Results: Increased adherence to EDII in the interaction with CAV1 genotypes led to an increase in leptin level 79.15 (mg/l) (β = 79.15, CI = − 1.23,163.94, P = 0.04) in model 3, after controlling for further potential confounders. By contrast, adherence to EDII in the interaction with the genotype including risk alleles showed no significant interaction, even after adjustment in model 3 (β = 0.55, CI = − 0.99, 2.09, P = 0.48). Although, a marginal positive significant interaction was found between EDII and CAV1 genotypes on Galectin 3, after adjustment in model 3 (β = 31.35, CI = 0.13, 77.13, P = 0.05). Conclusions: The present study indicates that a high adherence of EDII and CAV1 genotypes containing risk alleles may be a prognostic factor and increase both leptin and Galectin3. However, it seems that the presence of interaction was not on leptin resistance. Further functional studies are necessary to elucidate the exact mechanism. © 2022, The Author(s).

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Khadijeh Mirzaei (20)

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Style	Citing Format
MLA	Shiraseb F, et al.. "The Interaction Between Rs 3,807,992 Genotypes With the Dietary Inflammatory Index on Leptin, Leptin Resistance, and Galectin 3 in Obese and Overweight Women." BMC Endocrine Disorders, vol. 22, no. 1, 2022, pp. -.
APA	Shiraseb F, Farazi M, Rasaei N, Clark CCT, Jamili S, Mirzaei K (2022). The Interaction Between Rs 3,807,992 Genotypes With the Dietary Inflammatory Index on Leptin, Leptin Resistance, and Galectin 3 in Obese and Overweight Women. BMC Endocrine Disorders, 22(1), -.
Chicago	Shiraseb F, Farazi M, Rasaei N, Clark CCT, Jamili S, Mirzaei K. "The Interaction Between Rs 3,807,992 Genotypes With the Dietary Inflammatory Index on Leptin, Leptin Resistance, and Galectin 3 in Obese and Overweight Women." BMC Endocrine Disorders 22, no. 1 (2022): -.
Harvard	Shiraseb F et al. (2022) 'The Interaction Between Rs 3,807,992 Genotypes With the Dietary Inflammatory Index on Leptin, Leptin Resistance, and Galectin 3 in Obese and Overweight Women', BMC Endocrine Disorders, 22(1), pp. -.
Vancouver	Shiraseb F, Farazi M, Rasaei N, Clark CCT, Jamili S, Mirzaei K. The Interaction Between Rs 3,807,992 Genotypes With the Dietary Inflammatory Index on Leptin, Leptin Resistance, and Galectin 3 in Obese and Overweight Women. BMC Endocrine Disorders. 2022;22(1):-.
BibTex	@article{ author = {Shiraseb F and Farazi M and Rasaei N and Clark CCT and Jamili S and Mirzaei K}, title = {The Interaction Between Rs 3,807,992 Genotypes With the Dietary Inflammatory Index on Leptin, Leptin Resistance, and Galectin 3 in Obese and Overweight Women}, journal = {BMC Endocrine Disorders}, volume = {22}, number = {1}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Shiraseb F AU - Farazi M AU - Rasaei N AU - Clark CCT AU - Jamili S AU - Mirzaei K TI - The Interaction Between Rs 3,807,992 Genotypes With the Dietary Inflammatory Index on Leptin, Leptin Resistance, and Galectin 3 in Obese and Overweight Women JO - BMC Endocrine Disorders VL - 22 IS - 1 SP - EP - PY - 2022 ER -

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