Hif-1Α and Vegf Polymorphisms and Systemic Lupus Erythematosus Susceptibility

Hif-1Α and Vegf Polymorphisms and Systemic Lupus Erythematosus Susceptibility Publisher

Saravani M^{1, 2} ; Sandoughi M³ ; Heidary Z⁴ ; Ebrahimi G⁵ ; Mirzamohammadi S⁶ ; Haddadi M⁷ ; Nematollahi MH^{8, 9}

Show Affiliations

1. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
2. Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran
3. Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
4. Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
6. Department of Pharmacology, Shahroud University of Medical Sciences, Shahroud, Iran
7. Department of Biology, Faculty of Basic Sciences, University of Zabol, Zabol, Iran
8. Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
9. Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Source: Meta Gene Published:2021

Abstract

Background: Hypoxia-inducible factor-1α (HIF-1α) and its downstream gene, vascular endothelial factor (VEGF), play an important role in modulating the immune system function and consequently alternation the susceptibility to systemic lupus erythematosus (SLE) disease. Objective: The present study aimed to investigate the effect of the HIF-1α and VEGF gene polymorphisms and the susceptibility to SLE. Methods: The 140 patients and 150 healthy age and gender-matched people as a control group participated in the study. The PCR-RFLP method was used for genotyping. Results: No remarkable differences in allele frequencies of HIF-1α (rs11549465) and VEGF (rs699947) were seen between the SLE and control groups. The frequencies of CT genotype of the HIF-1α (rs11549465) and CA genotype of VEGF (rs699947) in the control were significantly higher than SLE group (OR = 0.53; 95% CI = 0.32–0.53; p = 0.014; OR = 0.57;95% CI = 0.33–0.99; p = 0.046, resp.). In the case of HIF-1α (C111A) polymorphism, the CA and AA variants were not found. Conclusion: HIF-1α (rs11549465) CT and VEGF (rs699947) CA genotypes were identified as protective factors for SLE. However, additional studies are required to confirm the association between HIF-1α and VEGF polymorphisms and SLE. © 2021

2. Impact of a 50Bp Insertion/Deletion Polymorphism of the Superoxide Dismutase-1 on Oxidative Stress Status and Risk of Keratoconus, Experimental Eye Research (2024)

3. Induction of Systemic Lupus Erythematosus-Like Syndrome in Balb/C Mice Leads to Disturbance in Splenic T Cell Subpopulations, Iranian Journal of Allergy# Asthma and Immunology (2021)

Style	Citing Format
MLA	Saravani M, et al.. "Hif-1Α and Vegf Polymorphisms and Systemic Lupus Erythematosus Susceptibility." Meta Gene, vol. 30, no. , 2021, pp. -.
APA	Saravani M, Sandoughi M, Heidary Z, Ebrahimi G, Mirzamohammadi S, Haddadi M, Nematollahi MH (2021). Hif-1Α and Vegf Polymorphisms and Systemic Lupus Erythematosus Susceptibility. Meta Gene, 30(), -.
Chicago	Saravani M, Sandoughi M, Heidary Z, Ebrahimi G, Mirzamohammadi S, Haddadi M, Nematollahi MH. "Hif-1Α and Vegf Polymorphisms and Systemic Lupus Erythematosus Susceptibility." Meta Gene 30, no. (2021): -.
Harvard	Saravani M et al. (2021) 'Hif-1Α and Vegf Polymorphisms and Systemic Lupus Erythematosus Susceptibility', Meta Gene, 30(), pp. -.
Vancouver	Saravani M, Sandoughi M, Heidary Z, Ebrahimi G, Mirzamohammadi S, Haddadi M, et al.. Hif-1Α and Vegf Polymorphisms and Systemic Lupus Erythematosus Susceptibility. Meta Gene. 2021;30():-.
BibTex	@article{ author = {Saravani M and Sandoughi M and Heidary Z and Ebrahimi G and Mirzamohammadi S and Haddadi M and Nematollahi MH}, title = {Hif-1Α and Vegf Polymorphisms and Systemic Lupus Erythematosus Susceptibility}, journal = {Meta Gene}, volume = {30}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Saravani M AU - Sandoughi M AU - Heidary Z AU - Ebrahimi G AU - Mirzamohammadi S AU - Haddadi M AU - Nematollahi MH TI - Hif-1Α and Vegf Polymorphisms and Systemic Lupus Erythematosus Susceptibility JO - Meta Gene VL - 30 IS - SP - EP - PY - 2021 ER -

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