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Acoustic and Optoacoustic Stimulations in Auditory Brainstem Response Test in Salicylate Induced Tinnitus Publisher Pubmed



Montazeri K1 ; Farhadi M1 ; Akbarnejad Z1 ; Asadpour A2 ; Majdabadi A3 ; Fekrazad R4 ; Mahmoudian S1
Authors
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Authors Affiliations
  1. 1. ENT and Head and Neck Research Center, The Five Senses Health Institute, School of Medicine, Hazrate Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, 1445613131, Iran
  2. 2. Intelligent Systems Research Centre, Ulster University, Derry Campus, Northern Ireland, Derry~Londonderry, United Kingdom
  3. 3. Laser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Radiation Sciences Research Center, Laser Research Center in Medical Sciences, AJA University of Medical Sciences, Tehran, Iran

Source: Scientific Reports Published:2023


Abstract

As a common debilitating disorder worldwide, tinnitus requires objective assessment. In the auditory brainstem response (ABR) test, auditory potentials can be evoked by acoustic or optoacoustic (induced by laser light) stimulations. In order to use the ABR test in the objective assessment of tinnitus, in this study, acoustic ABR (aABR) and optoacoustic ABR (oABR) were compared in the control and tinnitus groups to determine the changes caused by sodium salicylate (SS)-induced tinnitus in rat. In both aABR and oABR, wave II was the most prominent waveform, and the amplitude of wave II evoked by oABR was significantly higher than that of aABR. Brainstem transmission time (BTT), which represents the time required for a neural stimulation to progress from the auditory nerve ending to the inferior colliculus, was significantly shorter in oABR. In the tinnitus group, there was a significant increase in the threshold of both ABRs and a significant decrease in the amplitude of wave II only in the oABR. Based on our findings, the ABR test has the potential to be used in the assessment of SS-induced tinnitus, but oABR has the advantages of producing more prominent waveforms and significantly reducing the amplitude of wave II in tinnitus. © 2023, The Author(s).
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