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Diagnostic Significance of Serum Fatty Acid Synthase in Patients With Pancreatic Cancer Publisher



Fazli HR1 ; Moradzadeh M2 ; Mehrbakhsh Z3, 4 ; Sharafkhah M5 ; Masoudi S5 ; Pourshams A5 ; Mohamadkhani A5
Authors
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Authors Affiliations
  1. 1. Department of Genetics, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
  2. 2. Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  3. 3. Department of Biostaticstics, School of Health, Hamadan University of Medical sciences, Hamadan, Iran
  4. 4. Department of Biostaticstics, School of Health, Golestan University of Medical sciences, Gorgan, Iran
  5. 5. Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Middle East Journal of Digestive Diseases Published:2021


Abstract

BACKGROUND Pancreatic cancer is considered as the most deadly tumor among gastrointestinal cancers because of its poor prognosis. The frequently deregulated pathway in the cancer cell is associated with an increased expression of various genes, including the synthesis of fatty acids. We aimed to evaluate the level of serum fatty acid synthase (FASN) as a diagnostic marker for early diagnosis of pancreatic cancer. METHODS Serum FASN levels were measured by ELISA in 92 patients with pancreatic adenocarcinomas and in 92 healthy controls. Logistic regression analysis was used to identify independent predictors of certain diagnostic categories. RESULTS Serum FASN levels were significantly higher in patients with pancreatic cancer than in healthy controls (1.35 [0.98-2.3] ng/mL vs 1.04 [0.19-1.34] ng/mL, p < 0.001) and in smokers compared to non-smokers (1.41 [0.79-2.52] ng/mL vs 1.07 [0.21-1.74] ng/mL, p < 0.001). FASN levels and smoking were associated with increased risk of PC (1.54 [1.12.14] ng/mL, p = 0.011 and 5.69 [2.68-12.09] ng/mL, p < 0.001, respectively). CONCLUSION Elevated serum FASN levels in patients with pancreatic cancer indicate the need for the production of large numbers of lipids for the survival and proliferation of human cancer cells and the diagnostic value of FASN as a new diagnostic biomarker. © 2021 The Author(s).