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Gut Microbiota Alterations in Renal Transplant Recipients and the Risk of Urinary Tract Infection and Delayed Graft Function: A Preliminary Prospective Study Publisher Pubmed



Jelveh Moghaddam E1 ; Pourmand G2 ; Ahmadi Badi S3 ; Yarmohammadi H4, 5, 6 ; Soltanipur M4, 5, 6 ; Mahalleh M1 ; Rezaei M4, 6 ; Mirhosseini SM4 ; Siadat SD3, 6
Authors
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Authors Affiliations
  1. 1. Department of Urology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran
  4. 4. Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Quality of Life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  6. 6. Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran

Source: Urologia Journal Published:2024


Abstract

Background: The implication of gut microbiota in the gut-kidney axis affects the pathophysiology of chronic kidney disease (CKD). Gut microbiota composition changes during CKD. We aimed to determine the relative frequency of important gut microbiota members in end-stage renal disease (ERSD) patients before and after renal transplantation compared to healthy subjects. Methods: Fifteen kidney transplant patients and 10 healthy subjects were recruited in this case-control prospective study. Fecal samples were taken sequentially from all patients before kidney transplantation, 1 week, and 1 month after it. The relative frequency of Lactobacillus spp., Bifidobacterium spp., Akkermansia muciniphila, Bacteroides fragilis, Escherichia coli, and Faecalibacterium pruasnitzii were determined through quantitative PCR. The obtained data was statistically analyzed by Stata software (Stata Corporation, USA). Results: The mean log number of all bacteria was significantly higher in healthy individuals than kidney transplant recipients (p < 0.001) except for Lactobacillus where the mean levels were almost identical in the two groups (p = 0.67). Moreover, 20% (3) of patients developed a urinary tract infection. Besides, 2 (13.33%) patients were diagnosed with delayed graft function. There were no statistically significant differences regarding changing trends in bacteria log number of Akkermansia muciniphila (p = 0.12), Bacteroid fragilis (p = 0.75), Bifidobacterium (p = 0.99), Escherichia coli (p = 0.5), Faecalibacterium (p = 0.98), and Lactobacilli (p = 0.93) between patients with and without delayed graft function (DGF). Conclusion: Gut microbiota composition in patients with ESRD was significantly different from those without it. However, the microbiota profile did not significantly differ in patients with and without DGF. © The Author(s) 2024.