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Renal Involvement in Hospitalized Covid-19 Patients: Epidemiology, Risk Factors, and Correlation With Outcomes Publisher



Amini M1 ; Yaghoubi F1 ; Akhavan M1 ; Abbasloo S1 ; Tavakoli F1 ; Baghdadi A2 ; Hakemi MS1
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Authors Affiliations
  1. 1. Nephrology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Iranian Medical Council Published:2022


Abstract

Background: While respiratory tract symptoms are the most frequent reasons for hospital admission in COVID-19 patients, renal involvement is common and is associated with worse outcomes. The aim of this study was to determine the incidence, risk factors and outcome of Acute Kidney Injury (AKI) in hospitalized COVID-19 patients in a referral center. Methods: In a retrospective review, patients hospitalized for COVID-19 from February 2020 through April 2020 in a referral COVID center were studied. Demographic data, pre-existing comorbidities and drug history, along with laboratory data at presentation and during admission were recorded. AKI was diagnosed based on Kidney Disease Improving Global Outcomes (KDIGO) criteria. Data were analyzed to determine the incidence, risk factors and mortality of AKI. Results: Finally, 200 patients were included, with a mean age of 60.5 years. Of these, 126 (63%) developed AKI and this number was 73.5% among the ICU-admitted patients. Patients who developed AKI were 4.29 times more likely to die. Pre-existing CKD, treatment with immunosuppressant, ICU admission, and the need for hemodialysis, were significantly associated with mortality. Among the eleven renal transplant recipients in this study, we found that a prior renal transplant was not associated with a higher rate of AKI but was significantly associated with increased mortality after correcting for age and gender. Conclusion: Our findings showed a high incidence of AKI in patients admitted due to COVID-19, with a higher risk in ICU patients and it was a significant predictor of mortality. Further research is encouraged to understand the etiology of AKI, along with the long-term outcomes in the patients. Copyright 2022, Journal of Iranian Medical Council. All rights reserved.
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