Effects of Hydroalcoholic Extract of Berberis Integerrima on the Clinical Signs, Hs-Crp, Tnfα, and Esr in Active Rheumatoid Arthritis Patients

Effects of Hydroalcoholic Extract of Berberis Integerrima on the Clinical Signs, Hs-Crp, Tnfα, and Esr in Active Rheumatoid Arthritis Patients Publisher

Khorshidisedehi S¹ ; Aryaeian N¹ ; Shahram F² ; Akhlaghi M² ; Mahmoudi M² ; Motevalian M³ ; Asgari Taee F¹ ; Hosseini A⁴

Show Affiliations

1. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
2. Rheumatology Research Center, Shariaty Hospital, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
4. Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

Source: Journal of Herbal Medicine Published:2021

Abstract

Aim: To evaluate the effects of Barberry (Berberis integerrima) on clinical signs and inflammatory factors in patients with Rheumatoid arthritis (RA). Method: A total of 70 patients with active RA in a double-blind, placebo-controlled clinical trial (IRCT 201409249472N7) were randomly allocated to intervention and control groups. All the patients consumed 1500 mg of barberry extract and 1500 mg Hydroxypropyl methylcellulose (HPMC) each day respectively for three months. Clinical signs and serum levels of high-sensitivity C-reactive protein (hs-CRP), Tumor necrosis factor alpha (TNFα), and erythrocyte sedimentation rate (ESR) were measured before and after the intervention. Results: The results showed that consumption of the extract of Berberis integerrima resulted in a significant decrease in Visual Analog Scale (VAS), morning stiffness, number of tender joints, Disease Activity Score 28 (DAS28), Global Physician Assessment (GPA), serum levels of ESR, TNFα (p < 0.001), and hs-CRP (p < 0.01) in intervention group compared to the control group. Changes in the number of inflamed joints, the necessity for the administration of non-steroidal anti-inflammatory drugs (NSAIDs) (p = 0.02), and glucocorticoids (p < 0.001) were significant only in the intervention group. Conclusion: Barberry can improve clinical signs and inflammatory factors in RA patients and may be useful in their treatment approaches. © 2021 Elsevier GmbH

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Style	Citing Format
MLA	Khorshidisedehi S, et al.. "Effects of Hydroalcoholic Extract of Berberis Integerrima on the Clinical Signs, Hs-Crp, Tnfα, and Esr in Active Rheumatoid Arthritis Patients." Journal of Herbal Medicine, vol. 28, no. , 2021, pp. -.
APA	Khorshidisedehi S, Aryaeian N, Shahram F, Akhlaghi M, Mahmoudi M, Motevalian M, Asgari Taee F, Hosseini A (2021). Effects of Hydroalcoholic Extract of Berberis Integerrima on the Clinical Signs, Hs-Crp, Tnfα, and Esr in Active Rheumatoid Arthritis Patients. Journal of Herbal Medicine, 28(), -.
Chicago	Khorshidisedehi S, Aryaeian N, Shahram F, Akhlaghi M, Mahmoudi M, Motevalian M, Asgari Taee F, Hosseini A. "Effects of Hydroalcoholic Extract of Berberis Integerrima on the Clinical Signs, Hs-Crp, Tnfα, and Esr in Active Rheumatoid Arthritis Patients." Journal of Herbal Medicine 28, no. (2021): -.
Harvard	Khorshidisedehi S et al. (2021) 'Effects of Hydroalcoholic Extract of Berberis Integerrima on the Clinical Signs, Hs-Crp, Tnfα, and Esr in Active Rheumatoid Arthritis Patients', Journal of Herbal Medicine, 28(), pp. -.
Vancouver	Khorshidisedehi S, Aryaeian N, Shahram F, Akhlaghi M, Mahmoudi M, Motevalian M, et al.. Effects of Hydroalcoholic Extract of Berberis Integerrima on the Clinical Signs, Hs-Crp, Tnfα, and Esr in Active Rheumatoid Arthritis Patients. Journal of Herbal Medicine. 2021;28():-.
BibTex	@article{ author = {Khorshidisedehi S and Aryaeian N and Shahram F and Akhlaghi M and Mahmoudi M and Motevalian M and Asgari Taee F and Hosseini A}, title = {Effects of Hydroalcoholic Extract of Berberis Integerrima on the Clinical Signs, Hs-Crp, Tnfα, and Esr in Active Rheumatoid Arthritis Patients}, journal = {Journal of Herbal Medicine}, volume = {28}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Khorshidisedehi S AU - Aryaeian N AU - Shahram F AU - Akhlaghi M AU - Mahmoudi M AU - Motevalian M AU - Asgari Taee F AU - Hosseini A TI - Effects of Hydroalcoholic Extract of Berberis Integerrima on the Clinical Signs, Hs-Crp, Tnfα, and Esr in Active Rheumatoid Arthritis Patients JO - Journal of Herbal Medicine VL - 28 IS - SP - EP - PY - 2021 ER -

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