Preparation, Statistical Optimization and in Vitro Evaluation of Pramipexole Prolonged Delivery System Based on Poly (3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Nanoparticles

Preparation, Statistical Optimization and in Vitro Evaluation of Pramipexole Prolonged Delivery System Based on Poly (3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Nanoparticles Publisher

Bahari Javan N¹ ; Jafary Omid N¹ ; Moosavi Hasab N¹ ; Rezaie Shirmard L² ; Rafieetehrani M¹ ; Dorkoosh F^{1, 3}

Show Affiliations

1. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran
3. Medical Biomaterial Research Centre (MBRC), Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Drug Delivery Science and Technology Published:2018

Abstract

The purpose of the current study was to prepare and optimize a long acting formulation for pramipexole based on poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles (NPs). Pramipexole loaded PHBV NPs were prepared by double emulsion solvent evaporation technique. Box-behnken response surface methodology was utilized to assess the effect of independent variables including PVA concentration, polymer percentage and drug concentration on important properties of NPs. The optimized NPs was shown 228 nm size with 85.43% and 5.68% entrapment efficiency and loading capacity, respectively. The spherical structure of the pramipexole loaded PHBV NPs was proved by scanning electron microscope (SEM). Differential scanning calorimetry (DSC) testified both the absence of undesirable chemical interactions between pramipexole and NPs and the incorporation of pramipexole within the matrix of polymer. In vitro release studies demonstrated that 89.9% of pramipexole was gradually released within 30 days based on quasi-fickian diffusion mechanism. © 2017

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Style	Citing Format
MLA	Bahari Javan N, et al.. "Preparation, Statistical Optimization and in Vitro Evaluation of Pramipexole Prolonged Delivery System Based on Poly (3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Nanoparticles." Journal of Drug Delivery Science and Technology, vol. 44, no. , 2018, pp. 82-90.
APA	Bahari Javan N, Jafary Omid N, Moosavi Hasab N, Rezaie Shirmard L, Rafieetehrani M, Dorkoosh F (2018). Preparation, Statistical Optimization and in Vitro Evaluation of Pramipexole Prolonged Delivery System Based on Poly (3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Nanoparticles. Journal of Drug Delivery Science and Technology, 44(), 82-90.
Chicago	Bahari Javan N, Jafary Omid N, Moosavi Hasab N, Rezaie Shirmard L, Rafieetehrani M, Dorkoosh F. "Preparation, Statistical Optimization and in Vitro Evaluation of Pramipexole Prolonged Delivery System Based on Poly (3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Nanoparticles." Journal of Drug Delivery Science and Technology 44, no. (2018): 82-90.
Harvard	Bahari Javan N et al. (2018) 'Preparation, Statistical Optimization and in Vitro Evaluation of Pramipexole Prolonged Delivery System Based on Poly (3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Nanoparticles', Journal of Drug Delivery Science and Technology, 44(), pp. 82-90.
Vancouver	Bahari Javan N, Jafary Omid N, Moosavi Hasab N, Rezaie Shirmard L, Rafieetehrani M, Dorkoosh F. Preparation, Statistical Optimization and in Vitro Evaluation of Pramipexole Prolonged Delivery System Based on Poly (3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Nanoparticles. Journal of Drug Delivery Science and Technology. 2018;44():82-90.
BibTex	@article{ author = {Bahari Javan N and Jafary Omid N and Moosavi Hasab N and Rezaie Shirmard L and Rafieetehrani M and Dorkoosh F}, title = {Preparation, Statistical Optimization and in Vitro Evaluation of Pramipexole Prolonged Delivery System Based on Poly (3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Nanoparticles}, journal = {Journal of Drug Delivery Science and Technology}, volume = {44}, number = {}, pages = {82-90}, year = {2018} }
RIS	TY - JOUR AU - Bahari Javan N AU - Jafary Omid N AU - Moosavi Hasab N AU - Rezaie Shirmard L AU - Rafieetehrani M AU - Dorkoosh F TI - Preparation, Statistical Optimization and in Vitro Evaluation of Pramipexole Prolonged Delivery System Based on Poly (3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Nanoparticles JO - Journal of Drug Delivery Science and Technology VL - 44 IS - SP - 82 EP - 90 PY - 2018 ER -

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