The Effect of Telehealth on Alzheimer's Disease, Dementia and Mild Cognitive Impairment: A Systematic Review of Clinical Trials Publisher



Ghaddaripouri K ; Molavi R ; Montazeryan S ; Kharaghani MS ; Soudejani FT ; Vafamand M ; Erfannia L
Source: Healthcare Technology Letters Published:2026

Abstract

Alzheimer's disease is a prevalent chronic condition characterised by the gradual deterioration of memory and personal abilities due to nervous system damage, requiring prolonged care and management. In contemporary healthcare, telehealth has gained recognition as an effective approach for managing chronic illnesses by improving equitable access to quality medical services and minimising expenses. The purpose of this systematic review is to evaluate the role of telehealth in enhancing the well-being of patients with Alzheimer's disease and supporting their caregivers, as evidenced by findings from randomised controlled trials (RCTs). This systematic review concentrated on RCTs published in English, with no constraints on publication date. The search process was accomplished on 11 August, 2025, using appropriate keywords across well-established scientific databases, including PubMed, Embase, Scopus, ScienceDirect, Web of Science and ProQuest. The quality of the studies was assessed using the Joanna Briggs Institute checklist and only those scoring above seven were included in the analysis. From an initial collection of 1242 articles, 14 trials were ultimately included in this review. Telehealth interventions demonstrated significant improvements in cognitive function, mobility and quality of life among individuals with mild cognitive impairment and Alzheimer's Disease, while also reducing caregiver burden and psychological distress. These interventions, implemented through synchronous and asynchronous delivery methods, were deemed feasible, well-received and associated with strong adherence rates. Nonetheless, limitations such as small sample sizes and restricted access to technological resources emphasise the need for additional research to address these gaps. The findings from 13 out of 14 articles in this systematic review indicate that telehealth interventions, including virtual reality, video conferencing, computerised cognitive training and group movement programs, have the potential to significantly enhance health outcomes and quality of life for individuals with Alzheimer's disease and their caregivers compared to traditional in-person treatments. These interventions, delivered through diverse and flexible modalities, also demonstrate cost-effectiveness and improved caregiver well-being, reinforcing telehealth as a scalable and effective approach for comprehensive Alzheimer's care. © 2026 The Author(s). Healthcare Technology Letters published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology.