The Impact of Conventional Smoking Versus Electronic Cigarette on the Expression of Vegf, Pempa1, and Pten in Rat Prostate

The Impact of Conventional Smoking Versus Electronic Cigarette on the Expression of Vegf, Pempa1, and Pten in Rat Prostate Publisher

Shabestari AN¹ ; Tamehri Zadeh SS² ; Zahmatkesh P² ; Baghdadabad LZ² ; Mirzaei A² ; Mashhadi R² ; Mesbah G² ; Khajavi A³ ; Akbarzadehmoallemkolaei M⁴ ; Khoshchehreh M⁵ ; Rahimnia R⁶ ; Kazem Aghamir SM²

Show Affiliations

1. Department of Geriatric Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Student Research Committee, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Animal Model Integrated Network (AMIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran
5. Department of Pathology, University of California, Los Angeles, United States
6. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Prostate International Published:2023

Abstract

Background: The use of electronic cigarettes (e-cigarettes), the alternative to conventional smoking, is increasing considerably worldwide; however, their safety is a matter of debate. Several studies have demonstrated their toxic effects, but no study assessed their effects on the prostate. Objective: The current study aimed at evaluating e-cigarettes and conventional smoking prostate toxicity and effects on the expression of vascular endothelial growth factor A (VEGFA), phosphatase and tensin (PTEN), and prostate transmembrane protein androgen induced 1 (PMEPA1). Method: 30 young Wistar rats were categorized into three groups (n = 10) as follows: the control group, the conventional smoking group, and the e-cigarette group. The case groups were exposed to cigarettes or e-cigarettes for 40 minutes, 3 times a day for four months. Serum parameters, prostate pathology, and gene expression were measured at the end of the intervention. Data were analyzed by Graph Pad prism 9. Results: Histopathological findings presented that both types of cigarette-induced hyperemia and induced inflammatory cell infiltration and hypertrophy of smooth muscle of the vascular wall in the e-cigarette group. Expression of PMEPA1, and VEGFA genes significantly increased in conventional (2.67-fold; P = 0.0108, 1.80-fold; P = 0.0461 respectively) and e-cigarettes (1.98-fold; P = 0.0127, 1.34-fold; P = 0.938, respectively) groups compared to the control group. Expression of the PTEN gene non-significantly decreased in the case of groups compared to the control group. Conclusion: We found no significant differences between the two groups in terms of PTEN and PMEPA1 expression, whereas VEGFA was significantly more expressed in a conventional smoking group compared to the e-cigarette group. Therefore, it seems that e-cigarettes could not be taken into account as a better option than conventional smoking, and quitting smoking still is the optimal option. © 2022

Style	Citing Format
MLA	Shabestari AN, et al.. "The Impact of Conventional Smoking Versus Electronic Cigarette on the Expression of Vegf, Pempa1, and Pten in Rat Prostate." Prostate International, vol. 11, no. 2, 2023, pp. 76-82.
APA	Shabestari AN, Tamehri Zadeh SS, Zahmatkesh P, Baghdadabad LZ, Mirzaei A, Mashhadi R, Mesbah G, Khajavi A, Akbarzadehmoallemkolaei M, Khoshchehreh M, Rahimnia R, Kazem Aghamir SM (2023). The Impact of Conventional Smoking Versus Electronic Cigarette on the Expression of Vegf, Pempa1, and Pten in Rat Prostate. Prostate International, 11(2), 76-82.
Chicago	Shabestari AN, Tamehri Zadeh SS, Zahmatkesh P, Baghdadabad LZ, Mirzaei A, Mashhadi R, Mesbah G, et al.. "The Impact of Conventional Smoking Versus Electronic Cigarette on the Expression of Vegf, Pempa1, and Pten in Rat Prostate." Prostate International 11, no. 2 (2023): 76-82.
Harvard	Shabestari AN et al. (2023) 'The Impact of Conventional Smoking Versus Electronic Cigarette on the Expression of Vegf, Pempa1, and Pten in Rat Prostate', Prostate International, 11(2), pp. 76-82.
Vancouver	Shabestari AN, Tamehri Zadeh SS, Zahmatkesh P, Baghdadabad LZ, Mirzaei A, Mashhadi R, et al.. The Impact of Conventional Smoking Versus Electronic Cigarette on the Expression of Vegf, Pempa1, and Pten in Rat Prostate. Prostate International. 2023;11(2):76-82.
BibTex	@article{ author = {Shabestari AN and Tamehri Zadeh SS and Zahmatkesh P and Baghdadabad LZ and Mirzaei A and Mashhadi R and Mesbah G and Khajavi A and Akbarzadehmoallemkolaei M and Khoshchehreh M and Rahimnia R and Kazem Aghamir SM}, title = {The Impact of Conventional Smoking Versus Electronic Cigarette on the Expression of Vegf, Pempa1, and Pten in Rat Prostate}, journal = {Prostate International}, volume = {11}, number = {2}, pages = {76-82}, year = {2023} }
RIS	TY - JOUR AU - Shabestari AN AU - Tamehri Zadeh SS AU - Zahmatkesh P AU - Baghdadabad LZ AU - Mirzaei A AU - Mashhadi R AU - Mesbah G AU - Khajavi A AU - Akbarzadehmoallemkolaei M AU - Khoshchehreh M AU - Rahimnia R AU - Kazem Aghamir SM TI - The Impact of Conventional Smoking Versus Electronic Cigarette on the Expression of Vegf, Pempa1, and Pten in Rat Prostate JO - Prostate International VL - 11 IS - 2 SP - 76 EP - 82 PY - 2023 ER -

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