Omega 3-Induced Autophagy: A Two-Sided Sword in Cell Death From Historical Perspective in Clinical Application and Biological Mechanisms Publisher



Tabaeifard R ; Zare M ; Zendehdel A ; Ebrahimpour Koujan S
Source: International Journal of Nutrition Sciences Published:2025

Abstract

Omega-3 fatty acids, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and α-linolenic acid (ALA), are polyunsaturated fatty acids (PUFAs) with numerous health benefits. They play a critical role in various cellular functions, such as maintaining cell membrane integrity, cellular signaling pathways, and cell-to-cell communication. Omega-3s are known for their anti-inflammatory, anti-cancer, anti-depressant, and lipid-lowering properties. Autophagy, a cellular process responsible for recycling and degrading cellular components, is closely linked to these fatty acids. The impact of omega-3 fatty acids on autophagy signaling pathways hold promise for innovative therapeutic strategies in disease management and overall well-being. This review explores the influence of omega-3 fatty acids on autophagy and provides insights into the potential mechanisms involved. © 2025 Elsevier B.V., All rights reserved.