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Hormonal Influences on Cerebral Aneurysms: Unraveling the Complex Connections Publisher Pubmed



Segherlou ZH1 ; Shakeridarzekonani M2 ; Khavandegar A3 ; Stephenson S4 ; Ciccone K5 ; Masheghati F2 ; Hosseini Siyanaki MR6 ; Lyerly M7 ; Luckewold B1
Authors
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Authors Affiliations
  1. 1. Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL, United States
  2. 2. College of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. College of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Biotechnology Department, Krieger School of Arts and Sciences, John Hopkins University, Baltimore, MD, United States
  5. 5. Department of Behavioral Neuroscience, College of Arts and Sciences, University of North Florida, Jacksonville, FL, United States
  6. 6. Department of Radiology, College of Medicine, University of Florida, Gainesville, FL, United States
  7. 7. School of Medicine, Wake Forest University, Winston-Salem, NC, United States

Source: Expert Review of Endocrinology and Metabolism Published:2024


Abstract

Introduction: Intracranial aneurysms (IAs) occur in 3–5% of the general population and are characterized by localized structural deterioration of the arterial wall with loss of internal elastic lamina and disruption of the media. The risk of incidence and rupture of aneurysms depends on age, sex, ethnicity, and other different factors, indicating the influence of genetic and environmental factors. When an aneurysm ruptures, there is an estimated 20% mortality rate, along with an added 30–40% morbidity in survivors. The alterations in hormonal levels can influence IAs, while the rupture of an aneurysm can have various impacts on endocrine pathways and affect their outcome. Area covered: This review explores the reciprocal relationship between endocrinological changes (estrogen, growth hormone, and thyroid hormones) and IAs, as well as the effects of aneurysm ruptures on endocrine fluctuations. Expert opinion: Based on the data presented in this paper, we recommend further exploration into the influence of hormones on aneurysm formation and rupture. Additionally, we propose conducting endocrine assessments for patients who have experienced a rupture of IAs. Monitoring hormonal changes in patients with IAs could serve as a potential risk factor for rupture, leading to interventions in the approach to managing IAs. © 2024 Informa UK Limited, trading as Taylor & Francis Group.