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Rosai–Dorfman Disease: A Rare Clinicopathological Presentation and Review of the Literature Publisher Pubmed



Azariyaam A1 ; Abdolsalehi MR2 ; Vasei M1 ; Safavi M1 ; Mehdizadeh M3
Authors
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Authors Affiliations
  1. 1. Molecular Pathology and Cytogenetics Division, Department of Pathology, Children’s Medical Center, Tehran University of Medical Sciences, No 63, Gharib Ave, Keshavarz Blv, Tehran, 1419733151, Iran
  2. 2. Department of Infectious Diseases, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Radiology, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Head and Neck Pathology Published:2021


Abstract

Rosai–Dorfman disease (RDD) is a rare and self-limiting disease process that presents most commonly in young patients as massive, painless, cervical lymphadenopathy. Extranodal involvement may also occur. Histopathologic evaluation is the main diagnostic modality. We report an unusual presentation of RDD with cervical lymphadenopathy and an incidentally discovered sinonasal mass, clinically worrisome for malignancy. We emphasize that a high index of clinical suspicion is critical for accurate diagnosis of RDD. Clinicians and pathologists should consider RDD in a differential diagnosis of cervical lymphadenopathy, especially in young patients. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
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