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Novel Ph-Responsive Multilayer Magnetic Nanoparticles for Controlled Drug Delivery Publisher



Motevalizadeh SF1 ; Khoobi M2, 3 ; Babanejad N4 ; Mohit E5 ; Dehghankelishadi P2 ; Javar HA6 ; Dorkoosh FA2, 6 ; Faramarzi MA7 ; Shafiee A3
Authors
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Authors Affiliations
  1. 1. Particulate Fluids Processing Centre, School of Chemistry, University of Melbourne, Melbourne, 3010, VIC, Australia
  2. 2. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran
  4. 4. Department of Pure Chemistry, Faculty of Chemistry, Shahid Beheshti University, G.C., Tehran, Iran
  5. 5. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, P.O. Box 14155–6451, Tehran, 14176, Iran

Source: Journal of the Iranian Chemical Society Published:2016


Abstract

Abstract: A multifunctional nanocarrier with multilayer core–shell architecture was prepared by chemical modification of Fe3O4 magnetic nanoparticle (MNPs) with acrolein–styrene–polyethyleneimine (AL–St–PEI) via covalent bonding. MNPs were prepared by co-precipitation method, and then, thiol functionalized (MNPs-SH) were synthesized by treating MNPs with the (3-mercaptopropyl) trimethoxysilane. Subsequently, the copolymerization of St and AL was performed in the presence of the MNPs-SH and butyrolactam by thiol-lactam initiated radical polymerization. Finally, PEI was covalently bounded to the aldehyde groups on the surface of AL–St copolymer. The AL–St–PEI MNPs were investigated by FTIR, XRD, TGA, SEM and TEM. The drug release from AL–St–PEI MNPs was evaluated using doxorubicin as the model anticancer. Furthermore, to determine the effect of drug structure in the release profile from the modified MNPs, some lipophilic model drugs were studied in loading and release study. It was found that the nature of the drugs affect the release profile. The in vitro release modeling demonstrated that doxorubicin release is described by zero-order mechanism while release of lipophilic model drugs is controlled by fickian diffusion. Graphical Abstract: [Figure not available: see fulltext.] © 2016, Iranian Chemical Society.