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Eco-Friendly, Green and New Metal-Free Intramolecular Friedel–Crafts Reaction to Synthesis of Acridones Derivatives Using Phenylboronic Acid Derivatives Publisher



Askarzadeh M1 ; Moazzam A2 ; Sayahi MH3 ; Fouladvand A2 ; Adib M1 ; Mahdavi M2
Authors
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Authors Affiliations
  1. 1. School of Chemistry, College of Science, University of Tehran, Iran
  2. 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Chemistry, Payame Noor University (PNU), Tehran, Iran

Source: Tetrahedron Letters Published:2023


Abstract

Herein, we report a new, facile, versatile metal-free method for preparation of the various Acridones through an intramolecular carbonylation of 2-(phenylamino)benzoic acid derivatives and phenylboronic acid derivatives as activating agent for activation of carboxylic acid group in intramolecular C[sbnd]C bond formation through Friedel–Crafts reaction. The reaction proceeds under solvent-free conditions, tolerates a wide range of functional groups, and provides rapid access to a range of the Acridones in good to excellent yields. © 2023 Elsevier Ltd