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Strategic Priorities for Hematopoietic Stem Cell Transplantation in the Emro Region Publisher Pubmed



Ahmed SO1 ; Fakih RE1 ; Elhaddad A2 ; Hamidieh AA3 ; Altbakhi A4 ; Chaudhry QUN5 ; Bazarbachi A6 ; Adil S7 ; Alkhabori M8 ; Othman TB9 ; Gaziev J10 ; Khalaf M11 ; Alshammeri S12 ; Alotaibi S13 Show All Authors
Authors
  1. Ahmed SO1
  2. Fakih RE1
  3. Elhaddad A2
  4. Hamidieh AA3
  5. Altbakhi A4
  6. Chaudhry QUN5
  7. Bazarbachi A6
  8. Adil S7
  9. Alkhabori M8
  10. Othman TB9
  11. Gaziev J10
  12. Khalaf M11
  13. Alshammeri S12
  14. Alotaibi S13
  15. Alshahrani M13
  16. Bekadja MA14
  17. Ibrahim A15
  18. Alwahadneh AM16
  19. Altarshi M17
  20. Alsaeed A18
  21. Madani A19
  22. Abboud M6
  23. Abujazar H4
  24. Bakr M10
  25. Abosoudah I20
  26. Cheikh JE6
  27. Almasari A20
  28. Alfraih F1
  29. Baldomero H21
  30. Elsolh H1
  31. Niederwieser D22, 23
  32. Chaudhri N1
  33. Aljurf M1
Show Affiliations
Authors Affiliations
  1. 1. King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
  2. 2. National Cancer Institute, Cairo University, Cairo, Egypt
  3. 3. Tehran University of Medical Sciences, Hematology, Oncology & SCT Research Ctr., Tehran, Iran
  4. 4. King Hussein Cancer Center, Amman, Jordan
  5. 5. Armed Forces Bone Marrow Transplant Centre, National Institute of Blood and Marrow Transplant, Rawalpindi, Pakistan
  6. 6. Department of Hematology/Oncology, American University of Beirut Medical Center, Beirut, Lebanon
  7. 7. Department of Oncology, the Aga Khan University, Karachi, Pakistan
  8. 8. Sultan Qaboos University, Muscat, Oman
  9. 9. Center National de Greffe de Moelle Osseuse de Tunis, Tunis, Tunisia
  10. 10. National Center for Cancer Care & Research Hamad Medical Corporation, Doha, Qatar
  11. 11. Maadi Armed Forces Medical Compound Hematology, Oncology Hospital, Cairo, Egypt
  12. 12. Faculty of Medicine, Kuwait University, Jabriya, Kuwait
  13. 13. m Prince Sultan Military Medical City, Riyadh, Saudi Arabia
  14. 14. University Hospital Establishment 1st Nov, Oran, Algeria
  15. 15. Makassed General Hospital, Middle East Institute of Health, Beirut, Lebanon
  16. 16. Department of Pediatrics, Queen Rani Children’s Hospital, Amman, Jordan
  17. 17. The Royal Hospital, Muscat, Oman
  18. 18. King Abdulaziz Medical City, Ministry of National Guard, Jeddah, Saudi Arabia
  19. 19. Ibn Rochd University Hospital, University of Hassan II, Casablanca, Morocco
  20. 20. King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia
  21. 21. u University Hospital Basel, Basel, Switzerland
  22. 22. v Aichi Medical University Hospital, Nagakute, Japan
  23. 23. University, Leipzig, Germany

Source: Hematology/ Oncology and Stem Cell Therapy Published:2023


Abstract

The World Health Organization-designated Eastern Mediterranean region (EMRO) consists of 22 countries in North Africa and Western Asia with a collective population of over 679 million. The area comprises some of the wealthiest countries per capita income and some of the poorest. The population structure is also unique and contrasts with western countries, with a much younger population. The region sits in the heart of the thalassemia belt. Many countries have a significant prevalence of sickle cell disease, and cancer is on the rise in the region. Therefore, the strategic priorities for the growth and development of hematopoietic stem cell transplantation (HSCT) differ from country to country based on resources, healthcare challenges, and prevalent infrastructure. Thirty-one reporting teams to the Eastern Mediterranean Blood and Marrow Transplantation Group have active HSCT programs in 12 countries; allogeneic transplants outnumber autologous transplants, and the proportion of allotransplants for non-malignant conditions is higher in the EMRO region than in Western Europe and North America. The vast majority (99%) of allotransplants are from matched related donors. Matched unrelated donors and other alternate donor transplants are underutilized. The chance of finding a matched related donor for allografts is higher, with a significant chance of finding matched donors among non-sibling related donors. Reasons for relatively lower rates of transplants compared with other countries are multifactorial. Capacity building, development of newer centers, innovative funding, and better utilization of information technology are required to make transplantation as an accessible modality to more patients. Cost-effectiveness and cost-containment, regulation, and ensuring quality will all be priorities in planning HSCT development in the region. © 2023 King Faisal Specialist Hospital and Research Centre. All rights reserved.
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