Interaction Between Mirnas and 14-3-3 Proteins in Regulating Tumor Progression and Therapeutic Potentials

Interaction Between Mirnas and 14-3-3 Proteins in Regulating Tumor Progression and Therapeutic Potentials Publisher Pubmed

Yu J ; Ghavamikia N ; Hjazi A ; Altalbawy FMA ; Menon SV ; Kaur M ; Deorari M ; Gabal BC ; Saffarfar H ; Akhavansigari R

Source: Journal of Biochemical and Molecular Toxicology Published:2026

Abstract

The 14-3-3 biomolecules are highly conserved acidic eukaryotic proteins responsible for many cellular pathways, including cell cycle regulation, cell migration, and gene transcription control. Dysregulation of these proteins has been linked to the onset or suppression of cancers. Explorative studies have shown the positive and negative correlations between 14 and 3-3 proteins and oncomiRs or tumor suppressor miRNAs in cancer cells and supportive tissues during tumorigenesis, tumor progression, and metastasis. Understanding the interactions between 14 and 3-3 proteins and various miRNAs is crucial in introducing these proteins as novel prognostic cancer biomarkers. Furthermore, understanding the tumor-associated biological functions of 14-3-3 family proteins and targeting their interaction with specific miRNAs or directly manipulating 14-3-3 proteins may reveal their potential for cancer treatment in the future, as discussed in this review. © 2026 Wiley Periodicals LLC.

Related Docs

View other Related Docs

1. The Interaction Between Mirnas and 14-3-3Ζ Protein in Different Diseases, Protein and Peptide Letters (2025)

2. Microrna-181 Serves As a Dual-Role Regulator in the Development of Human Cancers, Free Radical Biology and Medicine (2020)

3. Mir-142-3P/5P Role in Cancer: From Epigenetic Regulation to Immunomodulation, Cell Biochemistry and Function (2024)

Style	Citing Format
MLA	Yu J, et al.. "Interaction Between Mirnas and 14-3-3 Proteins in Regulating Tumor Progression and Therapeutic Potentials." Journal of Biochemical and Molecular Toxicology, vol. 40, no. 3, 2026, pp. -.
APA	Yu J, Ghavamikia N, Hjazi A, Altalbawy FMA, Menon SV, Kaur M, Deorari M, Gabal BC, Saffarfar H, Akhavansigari R (2026). Interaction Between Mirnas and 14-3-3 Proteins in Regulating Tumor Progression and Therapeutic Potentials. Journal of Biochemical and Molecular Toxicology, 40(3), -.
Chicago	Yu J, Ghavamikia N, Hjazi A, Altalbawy FMA, Menon SV, Kaur M, Deorari M, Gabal BC, Saffarfar H, Akhavansigari R. "Interaction Between Mirnas and 14-3-3 Proteins in Regulating Tumor Progression and Therapeutic Potentials." Journal of Biochemical and Molecular Toxicology 40, no. 3 (2026): -.
Harvard	Yu J et al. (2026) 'Interaction Between Mirnas and 14-3-3 Proteins in Regulating Tumor Progression and Therapeutic Potentials', Journal of Biochemical and Molecular Toxicology, 40(3), pp. -.
Vancouver	Yu J, Ghavamikia N, Hjazi A, Altalbawy FMA, Menon SV, Kaur M, et al.. Interaction Between Mirnas and 14-3-3 Proteins in Regulating Tumor Progression and Therapeutic Potentials. Journal of Biochemical and Molecular Toxicology. 2026;40(3):-.
BibTex	@article{ author = {Yu J and Ghavamikia N and Hjazi A and Altalbawy FMA and Menon SV and Kaur M and Deorari M and Gabal BC and Saffarfar H and Akhavansigari R}, title = {Interaction Between Mirnas and 14-3-3 Proteins in Regulating Tumor Progression and Therapeutic Potentials}, journal = {Journal of Biochemical and Molecular Toxicology}, volume = {40}, number = {3}, pages = {-}, year = {2026} }
RIS	TY - JOUR AU - Yu J AU - Ghavamikia N AU - Hjazi A AU - Altalbawy FMA AU - Menon SV AU - Kaur M AU - Deorari M AU - Gabal BC AU - Saffarfar H AU - Akhavansigari R TI - Interaction Between Mirnas and 14-3-3 Proteins in Regulating Tumor Progression and Therapeutic Potentials JO - Journal of Biochemical and Molecular Toxicology VL - 40 IS - 3 SP - EP - PY - 2026 ER -

Science Communicator Platform

Authors

Abstract