Angina Bullosa Haemorrhagica-Like Lesions in Pemphigus Vulgaris Publisher Pubmed



Balighi K¹ ; Daneshpazhooh M¹ ; Aghazadeh N¹ ; Rahbar Z¹ ; Mahmoudi H¹ ; Sadjadi A¹ Show Affiliations
Source: Australasian Journal of Dermatology Published:2019

Abstract

Background/Objectives: The aim of this study was to describe a previously unreported association of oral pemphigus vulgaris with short-lived blood-filled painless blisters resembling angina bullosa haemorrhagica (ABH). Methods: A cross-sectional study of consecutive patients with Pemphigus vulgaris. All patients were examined for the presence of ABH-like lesions, and demographic, clinical and histopathological data were collected. Histopathological examination was performed when feasible. Results: A total of 318 with pemphigus vulgaris were included (63.5% female, mean age: 46 years). ABH-like lesions were present in 82 (25.8%) patients, commonly observed in the buccal mucosa (47, 57.3%) followed by the palate (15, 18.3%). All patients had normal platelet counts with no evidence of bleeding diathesis. Biopsies of the ABH-like lesions showed suprabasal clefts in four of six samples. ABH-like lesions were significantly associated with partial remission of pemphigus vulgaris (47.5%, P = 0.002) and the use of intraoral steroids (P = 0.001, odds ratio: 5.9 [95% confidence interval: 2.5–13.6]). Conclusion: ABH-like lesions may represent a transient or abortive form of oral pemphigus vulgaris and tend to have a benign and self-limiting nature. © 2018 The Australasian College of Dermatologists