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Novel Osteoprotective Nanocochleate Formulation: A Dual Combination Therapy-Codelivery System Against Glucocorticoid Induced Osteoporosis Publisher Pubmed



Eskandarynasab M1 ; Etemadmoghadam S2 ; Alaeddini M2 ; Doustimotlagh AH3 ; Nazeri A4 ; Dehpour AR1, 6 ; Goudarzi R5 ; Partoazar A1, 6
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
  4. 4. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Division of Research and Development, Pharmin USA, LLC, San Jose, United States
  6. 6. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Nanomedicine: Nanotechnology# Biology# and Medicine Published:2020


Abstract

Phosphatidylserine nanocochleates (Nanocochs) are novel delivery systems that may play a prominent osteoprotective role with their cargo, vitamin D3 (Vit-D3), against osteoporosis. Therefore, this study was conducted to characterize a Nanococh containing vitamin D3 (Nanococh-D3) and investigate its potential role in improving GIO in a rat model. Roll-shaped Nanococh-D3 particles were obtained in a size range of 320 nm with a sustained release performance. Oral Nanococh-D3 significantly increased the bioavailability of Vit-D3, enhanced bone mechanical strength, and improved osteogenic biomarkers including B-ALP, osteocalcin, Ca, and OPG in GIO rats. This formulation markedly suppressed gene expression of RANK and RANKL in treated rats. Histomorphometric analysis showed significant repairs in bone tissues and TRAP staining indicated a significant decrease in osteoclasts using Nanococh-D3 in osteoporotic rats. Nanococh alone similar to Nanococh-D3 acted better than AL as a standard anti-osteoporotic drug in the improvement of bone strength. In conclusion, our results established the potential role of Nanococh-D3 against osteoporosis in rats. © 2020 Elsevier Inc.
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Alireza Partoazar (5)
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