The Effect of Melatonin on Improving the Benign Prostatic Hyperplasia Urinary Symptoms, a Randomized Clinical Trial

The Effect of Melatonin on Improving the Benign Prostatic Hyperplasia Urinary Symptoms, a Randomized Clinical Trial Publisher Pubmed

Fotovat A¹ ; Samadzadeh B² ; Ayati M¹ ; Nowroozi MR¹ ; Momeni SA¹ ; Yavari S³ ; Nasseri A⁴ ; Sharifi L¹

Show Affiliations

1. Uro-Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Urology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
3. Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4. Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Urology Journal Published:2022

Abstract

Purpose: to investigate the effect of melatonin along with tamsulosin in improving BPH urinary symptoms. Materials and Methods: A total of 108 men with BPH symptoms, age of ≥ 50 years, and International Prostate Symptom Score (IPSS) ≥ 8 entered into the parallel group randomized, double-blind clinical trial with balanced randomization. The treatment group received of 3mg melatonin plus 0.4mg tamsulosin and the control group received placebo plus 0.4mg tamsulosin. Patients and physicians were concealed by sealed and opaque envelopes. Symptoms were assessed at baseline and 1 month after treatment. Finally all scores at the initial and end of the study were compared and analyzed using SPSS software. Results: This study showed that adding melatonin to the classic treatment of BPH patients with tamsulosin could significantly reduce the likelihood of nocturia by 2.39 times (95% CI: 1.07-5.32, OR = 2.39, p = 0.033) and could also reduce the frequency of urination by 2.59 times (95% CI: 1.15-5.84, OR = 2.59, p = 0.021). There was no statistically significant difference between the two groups in IPSS, intermittency, incomplete emptying, straining, urgency, and weak stream. Conclusion: Melatonin plus tamsulosin treatment is associated with a significant improvement of nocturia and frequency in patients with benign proststic hyperplasia. However, it is necessary to do more studies. © 2022, Urology Journal. All Rights Reserved.

Style	Citing Format
MLA	Fotovat A, et al.. "The Effect of Melatonin on Improving the Benign Prostatic Hyperplasia Urinary Symptoms, a Randomized Clinical Trial." Urology Journal, vol. 19, no. 5, 2022, pp. 406-411.
APA	Fotovat A, Samadzadeh B, Ayati M, Nowroozi MR, Momeni SA, Yavari S, Nasseri A, Sharifi L (2022). The Effect of Melatonin on Improving the Benign Prostatic Hyperplasia Urinary Symptoms, a Randomized Clinical Trial. Urology Journal, 19(5), 406-411.
Chicago	Fotovat A, Samadzadeh B, Ayati M, Nowroozi MR, Momeni SA, Yavari S, Nasseri A, Sharifi L. "The Effect of Melatonin on Improving the Benign Prostatic Hyperplasia Urinary Symptoms, a Randomized Clinical Trial." Urology Journal 19, no. 5 (2022): 406-411.
Harvard	Fotovat A et al. (2022) 'The Effect of Melatonin on Improving the Benign Prostatic Hyperplasia Urinary Symptoms, a Randomized Clinical Trial', Urology Journal, 19(5), pp. 406-411.
Vancouver	Fotovat A, Samadzadeh B, Ayati M, Nowroozi MR, Momeni SA, Yavari S, et al.. The Effect of Melatonin on Improving the Benign Prostatic Hyperplasia Urinary Symptoms, a Randomized Clinical Trial. Urology Journal. 2022;19(5):406-411.
BibTex	@article{ author = {Fotovat A and Samadzadeh B and Ayati M and Nowroozi MR and Momeni SA and Yavari S and Nasseri A and Sharifi L}, title = {The Effect of Melatonin on Improving the Benign Prostatic Hyperplasia Urinary Symptoms, a Randomized Clinical Trial}, journal = {Urology Journal}, volume = {19}, number = {5}, pages = {406-411}, year = {2022} }
RIS	TY - JOUR AU - Fotovat A AU - Samadzadeh B AU - Ayati M AU - Nowroozi MR AU - Momeni SA AU - Yavari S AU - Nasseri A AU - Sharifi L TI - The Effect of Melatonin on Improving the Benign Prostatic Hyperplasia Urinary Symptoms, a Randomized Clinical Trial JO - Urology Journal VL - 19 IS - 5 SP - 406 EP - 411 PY - 2022 ER -

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