Synthesis of Novel Tacrine Analogs As Acetylcholinesterase Inhibitors

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Synthesis of Novel Tacrine Analogs As Acetylcholinesterase Inhibitors Publisher

Mahdavi M¹ ; Saeedi M^{2, 3} ; Gholamnia L¹ ; Jeddi SAB⁴ ; Sabourian R³ ; Shafiee A¹ ; Foroumadi A¹ ; Akbarzadeh T^{3, 4}

Source: Journal of Heterocyclic Chemistry Published:2017

Abstract

In this work, a wide range of novel pyrazolo[4′,3′:5,6]pyrano[2,3-b]quinolin-5-amines were synthesized as tacrine analogs. At first, reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one, aromatic aldehydes, and malononitrile gave 6-amino-4-aryl-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles. Then, reaction of the latter compounds with cyclohexanone led to the formation of the title compounds. Also, they were evaluated for their in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activities. Interestingly, most of them showed good inhibitory activity comparing with rivastigmine as the reference drug. © 2016 Wiley Periodicals, Inc.

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Style	Citing Format
MLA	Mahdavi M, et al.. "Synthesis of Novel Tacrine Analogs As Acetylcholinesterase Inhibitors." Journal of Heterocyclic Chemistry, vol. 54, no. 1, 2017, pp. 384-390.
APA	Mahdavi M, Saeedi M, Gholamnia L, Jeddi SAB, Sabourian R, Shafiee A, Foroumadi A, Akbarzadeh T (2017). Synthesis of Novel Tacrine Analogs As Acetylcholinesterase Inhibitors. Journal of Heterocyclic Chemistry, 54(1), 384-390.
Chicago	Mahdavi M, Saeedi M, Gholamnia L, Jeddi SAB, Sabourian R, Shafiee A, Foroumadi A, Akbarzadeh T. "Synthesis of Novel Tacrine Analogs As Acetylcholinesterase Inhibitors." Journal of Heterocyclic Chemistry 54, no. 1 (2017): 384-390.
Harvard	Mahdavi M et al. (2017) 'Synthesis of Novel Tacrine Analogs As Acetylcholinesterase Inhibitors', Journal of Heterocyclic Chemistry, 54(1), pp. 384-390.
Vancouver	Mahdavi M, Saeedi M, Gholamnia L, Jeddi SAB, Sabourian R, Shafiee A, et al.. Synthesis of Novel Tacrine Analogs As Acetylcholinesterase Inhibitors. Journal of Heterocyclic Chemistry. 2017;54(1):384-390.
BibTex	@article{ author = {Mahdavi M and Saeedi M and Gholamnia L and Jeddi SAB and Sabourian R and Shafiee A and Foroumadi A and Akbarzadeh T}, title = {Synthesis of Novel Tacrine Analogs As Acetylcholinesterase Inhibitors}, journal = {Journal of Heterocyclic Chemistry}, volume = {54}, number = {1}, pages = {384-390}, year = {2017} }
RIS	TY - JOUR AU - Mahdavi M AU - Saeedi M AU - Gholamnia L AU - Jeddi SAB AU - Sabourian R AU - Shafiee A AU - Foroumadi A AU - Akbarzadeh T TI - Synthesis of Novel Tacrine Analogs As Acetylcholinesterase Inhibitors JO - Journal of Heterocyclic Chemistry VL - 54 IS - 1 SP - 384 EP - 390 PY - 2017 ER -

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