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Microbial Natural Compounds and Secondary Metabolites As Immunomodulators: A Review Publisher Pubmed



Mahmoudi F1 ; Jalayeri MHT2 ; Montaseri A3 ; Mohamedkhosroshahi L4 ; Baradaran B1
Authors
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Authors Affiliations
  1. 1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital Golestan University of Medical Sciences, Gorgan, Iran
  3. 3. Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Unit of Histology and Medical Embryology, Sapienza University of Rome, Rome, 00161, Italy
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Science, Tehran, Iran

Source: International Journal of Biological Macromolecules Published:2024


Abstract

Immunomodulatory therapies are beneficial strategies for the improvement of immune system function. Today, due to the increasing prevalence of immune disorders, cancer, and new viral diseases, there is a greater need to introduce immunomodulatory compounds with more efficiency and fewer side effects. Microbial derivatives are fertile and attractive grounds for discovering lots of novel compounds with various medical properties. The discovery of many natural compounds derived from bacterial sources, such as secondary metabolites with promising immunomodulating activities, represents the importance of this topic in drug discovery and emphasizes the necessity for a coherent source of study in this area. Considering this need, in this review, we aim to focus on the current information about the immunomodulatory effects of bacterial secondary metabolites and natural immunomodulators derived from microorganisms. © 2024 Elsevier B.V.
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