Ameliorating Age-Dependent Effects of Resveratrol on Vpa-Induced Social Impairments and Anxiety-Like Behaviors in a Rat Model of Neurodevelopmental Disorder

Ameliorating Age-Dependent Effects of Resveratrol on Vpa-Induced Social Impairments and Anxiety-Like Behaviors in a Rat Model of Neurodevelopmental Disorder Publisher Pubmed

Shahrbabaki SSV¹ ; Moslemizadeh A² ; Amiresmaili S³ ; Tezerji SS⁴ ; Juybari KB⁵ ; Sepehri G⁶ ; Shamsi Meymandi M⁶ ; Bashiri H⁶

Show Affiliations

1. Department of Biology, University of Turku, Turku, 20014, Finland
2. Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Physiology, Bam University of Medical Sciences, Bam, Iran
4. Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
5. Department of Pharmacology, Shcool of Medicine, Semnan University of Medical Sciences, Semnan, Iran
6. Neuroscience Research Center, Institute of Neuropharmacology, Department of Physiology and Pharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Source: NeuroToxicology Published:2023

Abstract

Although anxiety disorders, as well as difficulties in social interaction, are documented in children with autism spectrum disorder (ASD) as a neurodevelopmental disorder, the effectiveness of potential therapeutic procedures considering age and sex differences is under serious discussion. The present study aimed to investigate the effect of resveratrol (RSV) on anxiety-like behaviors and social interaction in juvenile and adult rats of both sex in a valproic acid (VPA)-induced autistic-like model. Prenatal exposure to VPA was associated with increased anxiety, also causing a significant reduction in social interaction in juvenile male subjects. Further administration of RSV attenuated VPA-induced anxiety symptoms in both sexes of adult animals and significantly increased the sociability index in male and female juvenile rats. Taken together, it can be concluded that treatment with RSV can attenuate some of the harsh effects of VPA. This treatment was especially effective on anxiety-like traits in adult subjects of both sexes regarding their performance in open field and EPM. We encourage future research to consider the sex and age-specific mechanisms behind the RSV treatment in the prenatal VPA model of autism. © 2023 Elsevier B.V.

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Style	Citing Format
MLA	Shahrbabaki SSV, et al.. "Ameliorating Age-Dependent Effects of Resveratrol on Vpa-Induced Social Impairments and Anxiety-Like Behaviors in a Rat Model of Neurodevelopmental Disorder." NeuroToxicology, vol. 96, no. , 2023, pp. 154-165.
APA	Shahrbabaki SSV, Moslemizadeh A, Amiresmaili S, Tezerji SS, Juybari KB, Sepehri G, Shamsi Meymandi M, Bashiri H (2023). Ameliorating Age-Dependent Effects of Resveratrol on Vpa-Induced Social Impairments and Anxiety-Like Behaviors in a Rat Model of Neurodevelopmental Disorder. NeuroToxicology, 96(), 154-165.
Chicago	Shahrbabaki SSV, Moslemizadeh A, Amiresmaili S, Tezerji SS, Juybari KB, Sepehri G, Shamsi Meymandi M, Bashiri H. "Ameliorating Age-Dependent Effects of Resveratrol on Vpa-Induced Social Impairments and Anxiety-Like Behaviors in a Rat Model of Neurodevelopmental Disorder." NeuroToxicology 96, no. (2023): 154-165.
Harvard	Shahrbabaki SSV et al. (2023) 'Ameliorating Age-Dependent Effects of Resveratrol on Vpa-Induced Social Impairments and Anxiety-Like Behaviors in a Rat Model of Neurodevelopmental Disorder', NeuroToxicology, 96(), pp. 154-165.
Vancouver	Shahrbabaki SSV, Moslemizadeh A, Amiresmaili S, Tezerji SS, Juybari KB, Sepehri G, et al.. Ameliorating Age-Dependent Effects of Resveratrol on Vpa-Induced Social Impairments and Anxiety-Like Behaviors in a Rat Model of Neurodevelopmental Disorder. NeuroToxicology. 2023;96():154-165.
BibTex	@article{ author = {Shahrbabaki SSV and Moslemizadeh A and Amiresmaili S and Tezerji SS and Juybari KB and Sepehri G and Shamsi Meymandi M and Bashiri H}, title = {Ameliorating Age-Dependent Effects of Resveratrol on Vpa-Induced Social Impairments and Anxiety-Like Behaviors in a Rat Model of Neurodevelopmental Disorder}, journal = {NeuroToxicology}, volume = {96}, number = {}, pages = {154-165}, year = {2023} }
RIS	TY - JOUR AU - Shahrbabaki SSV AU - Moslemizadeh A AU - Amiresmaili S AU - Tezerji SS AU - Juybari KB AU - Sepehri G AU - Shamsi Meymandi M AU - Bashiri H TI - Ameliorating Age-Dependent Effects of Resveratrol on Vpa-Induced Social Impairments and Anxiety-Like Behaviors in a Rat Model of Neurodevelopmental Disorder JO - NeuroToxicology VL - 96 IS - SP - 154 EP - 165 PY - 2023 ER -

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