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A Retrospective Study on the Gam-Covid-Vac (Sputnik V) Covid-19 Vaccine Short-Term Efficacy and Side Effects in Iranian Healthcare Providers Publisher



Tameshkel FS1 ; Dargoush SA2 ; Goudarzi M3 ; Tabibzadeh A4 ; Ghiaseddin A5 ; Ranjbar M6 ; Alomohamadi Y7 ; Zamani F1 ; Vaez A3 ; Rahimian N8 ; Makiani MJ6, 9 ; Divsalar F10 ; Gholizadeh E1 ; Niya MHK1, 4
Authors
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Authors Affiliations
  1. 1. Gastrointestinal and Liver Diseases Research Center, Iran University of Medical sciences, Tehran, Iran
  2. 2. Stem Cell and Regenerative Medicine Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Internal Medicine, School of Medicine, Firoozgar General Hospital, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Chemistry Department, Michigan State University, Lansing, MI, United States
  6. 6. Department of Infectious Diseases, School of Medicine, Firoozgar General Hospital, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  8. 8. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran
  9. 9. Antimicrobial Resistant Research Center, Iran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Infectious Diseases and Tropical Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Archives of Clinical Infectious Diseases Published:2023


Abstract

Background: The Gam-COVID-Vac (Sputnik V) COVID-19 vaccine is one of the approved vaccines which has been used in Iran. Objectives: In the present retrospective study, we evaluated the short-term efficacy and side effects of the Sputnik V vaccine against COVID-19 in Iranian healthcare providers. Methods: Healthcare workers referred to Firoozgar Hospital affiliated with the Iran University of Medical Sciences, Tehran, Iran, between March 2021 and December 2021 were assessed. Humoral immunity was evaluated against S-RBD IgG of SARS-CoV2 after Sputnik V vaccination at three phases, including days 60 (phase I), 120 (phase II), and 210 (phase III) by an anti-S RBD IgG ELISA kit. Vaccine recipients were divided into two groups based on the history of SARS-CoV2 infection. The vaccine side effects were obtained from each participant after the first and second doses. Results: A total of 65 vaccine recipients (41.5% male (27/65)) with a mean age of 35 ± 8.5 years were enrolled, of whom 41.5% had a history of COVID-19 infection. The SARS-CoV-2 IgG levels were significantly higher in vaccine recipients compared to those without a history of COVID-19 infection a month (4 vs. 6.6), three months (4.5 vs. 7.2), and six months (3.8 vs. 5.9) after vaccination (P = 0.001). Our study had 18 patients (27.7%) with vaccination breakthroughs. Conclusions: Sputnik V seems to induce high antibody levels after the second dose; however, protective antibodies declined six months after the second dose. A booster dose is highly recommended for at-risk individuals. © 2023, Author(s).
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