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Identification of a Novel Human Rhinovirus C Type by Antibody Capture Vidisca-454 Publisher Pubmed



Farsani SMJ1, 2 ; Munnink BBO1 ; Canuti M1, 5 ; Deijs M1 ; Cotten M3 ; Jebbink MF1 ; Verhoeven J1, 5 ; Kellam P3 ; Loens K4 ; Goossens H4 ; Ieven M4 ; Van Der Hoek L1
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Authors Affiliations
  1. 1. Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam, 1105, AZ, Netherlands
  2. 2. Department of Virology, Tehran University of Medical Sciences, Tehran, 14176-14411, Iran
  3. 3. Department of Virus Genomics, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, United Kingdom
  4. 4. Department of Medical Microbiology, Vaccine and Infectious Disease Institute, University Hospital, Antwerp, B-2650, Belgium
  5. 5. Department of Biology, Memorial University of Newfoundland, St John’s, A1B 3X9, NL, Canada

Source: Viruses Published:2015


Abstract

Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discovery of a novel type of rhinovirus C (RV-C). The virus has an RNA genome of at least 7054 nt and carries the characteristics of rhinovirus C species. The gene encoding viral protein 1, which is used for typing, has only 81% nucleotide sequence identity with the closest known RV-C type, and, therefore, the virus represents the first member of a novel type, named RV-C54. © 2015 by the authors; licensee MDPI, Basel, Switzerland.
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