Protein and Antibody Engineering: Suppressing Degranulation of the Mast Cells and Type I Hypersensitivity Reaction

Protein and Antibody Engineering: Suppressing Degranulation of the Mast Cells and Type I Hypersensitivity Reaction Publisher Pubmed

Rajani HF¹ ; Shahidi S² ; Gomari MM¹

Show Affiliations

1. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Current Protein and Peptide Science Published:2020

Abstract

With an increase in atopic cases and owing to a significant role of mast cells in type I hypersensitivity, a therapeutic need to inhibit degranulation of mast cells has risen. Mast cells are notorious for IgE-mediated allergic response. Advancements have allowed researchers to improve clinical outcomes of already available therapies. Engineered peptides and antibodies can be easily manipulated to attain desired characteristics as per the biological environment. A number of these molecules are designed to target mast cells in order to regulate the release of histamine and other mediators, thereby controlling type I hypersensitivity response. The aim of this review paper is to highlight some of the significant molecules designed for the purpose. . © 2020 Bentham Science Publishers.

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Style	Citing Format
MLA	Rajani HF, Shahidi S, Gomari MM. "Protein and Antibody Engineering: Suppressing Degranulation of the Mast Cells and Type I Hypersensitivity Reaction." Current Protein and Peptide Science, vol. 21, no. 8, 2020, pp. 831-841.
APA	Rajani HF, Shahidi S, Gomari MM (2020). Protein and Antibody Engineering: Suppressing Degranulation of the Mast Cells and Type I Hypersensitivity Reaction. Current Protein and Peptide Science, 21(8), 831-841.
Chicago	Rajani HF, Shahidi S, Gomari MM. "Protein and Antibody Engineering: Suppressing Degranulation of the Mast Cells and Type I Hypersensitivity Reaction." Current Protein and Peptide Science 21, no. 8 (2020): 831-841.
Harvard	Rajani HF, Shahidi S, Gomari MM (2020) 'Protein and Antibody Engineering: Suppressing Degranulation of the Mast Cells and Type I Hypersensitivity Reaction', Current Protein and Peptide Science, 21(8), pp. 831-841.
Vancouver	Rajani HF, Shahidi S, Gomari MM. Protein and Antibody Engineering: Suppressing Degranulation of the Mast Cells and Type I Hypersensitivity Reaction. Current Protein and Peptide Science. 2020;21(8):831-841.
BibTex	@article{ author = {Rajani HF and Shahidi S and Gomari MM}, title = {Protein and Antibody Engineering: Suppressing Degranulation of the Mast Cells and Type I Hypersensitivity Reaction}, journal = {Current Protein and Peptide Science}, volume = {21}, number = {8}, pages = {831-841}, year = {2020} }
RIS	TY - JOUR AU - Rajani HF AU - Shahidi S AU - Gomari MM TI - Protein and Antibody Engineering: Suppressing Degranulation of the Mast Cells and Type I Hypersensitivity Reaction JO - Current Protein and Peptide Science VL - 21 IS - 8 SP - 831 EP - 841 PY - 2020 ER -

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