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Hyoscine Versus Diazepam for the Management of True Vertigo in the Emergency Department Publisher



Kariman H1 ; Vajihi F1 ; Amini A1 ; Shahrami A1 ; Arhamidolatabadi A1 ; Shojaee M1 ; Baratloo A2
Authors
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Authors Affiliations
  1. 1. Department of Emergency Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Emergency Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Bangladesh Journal of Pharmacology Published:2017


Abstract

The present study was a double-blind clinical trial to compare the efficiency of hysocine and diazepam in vertigo treatment. Eligible patients (n=69) were randomly divided into 2 groups of 5 mg hyoscine and 10 mg diazepam. Severity of vertigo was measured in supine and sitting position, and while turning the head. Vertigo severity was assessed before, and 1 and 2 hours after administration of the drug. Treatment success rate of diazepam in relieving vertigo in different positions varied between 88.9 and 100%, while this rate was 31.2–73.5% in hyoscine treatment group (p<0.01). Prescription of diazepam led to complete relief of vertigo in 40–63% of the patients, while this rate was only 2.6–12.5% in hyoscine treatment group (p<0.001). It is likely that diazepam is a better option than hyoscine for management of true vertigo in patients presenting to the emergency department. © 2017, Bangladesh Pharmacological Society. All rights reserved.