From Proton Transferred to Cyclometalated Platinum(Iv) Complex: Crystal Structure and Biological Activity

From Proton Transferred to Cyclometalated Platinum(Iv) Complex: Crystal Structure and Biological Activity Publisher

Abedi A¹ ; Amani V² ; Safari N² ; Ostad SN³ ; Notash B²

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1. Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, 19585-936, Iran
2. Department of Chemistry, Shahid Beheshti University, G. C., Evin, Tehran, 19839-63113, Iran
3. Department of Toxicology and Pharmacology, University of Tehran Medical Sciences, Tehran, 14155-6451, Iran

Source: Journal of Organometallic Chemistry Published:2015

Abstract

A new proton transfer complex of [6,6′-dmbipy.H]2[PtCl6] (1) was prepared from the reaction of H2PtCl6.6H2O with 6,6′-dimethyl-2,2'-bipyridine (6,6′-dmbipy) in CH3CN at room temperature. The cyclometalated complex of mer-[Pt(6,6′-dmbipy-κ2N,C)Cl3(DMF-κO)] (2) was prepared from the recrystallization of complex 1, in a mixture of DMF/DMSO/H2O (6:2:1) at 60 °C, in which the first C-H bond activation in a bipyridine ring with Pt(IV) ion was observed. In vitro cytotoxicity against four cultures: NIH-3T3, Caco-2, HT-29 and T47D were studied using MTT assays. Interestingly, compound 2 is more potent in killing a colon cancer cell line than cisplatin, since it exhibits extensively less toxicity on normal cells. Both complexes were characterized by elemental analysis, FT-IR, 1H NMR, UV-Vis spectra and X-ray crystallography. © 2015 Elsevier B.V. All rights reserved.

Style	Citing Format
MLA	Abedi A, et al.. "From Proton Transferred to Cyclometalated Platinum(Iv) Complex: Crystal Structure and Biological Activity." Journal of Organometallic Chemistry, vol. 799-800, no. , 2015, pp. 30-37.
APA	Abedi A, Amani V, Safari N, Ostad SN, Notash B (2015). From Proton Transferred to Cyclometalated Platinum(Iv) Complex: Crystal Structure and Biological Activity. Journal of Organometallic Chemistry, 799-800(), 30-37.
Chicago	Abedi A, Amani V, Safari N, Ostad SN, Notash B. "From Proton Transferred to Cyclometalated Platinum(Iv) Complex: Crystal Structure and Biological Activity." Journal of Organometallic Chemistry 799-800, no. (2015): 30-37.
Harvard	Abedi A et al. (2015) 'From Proton Transferred to Cyclometalated Platinum(Iv) Complex: Crystal Structure and Biological Activity', Journal of Organometallic Chemistry, 799-800(), pp. 30-37.
Vancouver	Abedi A, Amani V, Safari N, Ostad SN, Notash B. From Proton Transferred to Cyclometalated Platinum(Iv) Complex: Crystal Structure and Biological Activity. Journal of Organometallic Chemistry. 2015;799-800():30-37.
BibTex	@article{ author = {Abedi A and Amani V and Safari N and Ostad SN and Notash B}, title = {From Proton Transferred to Cyclometalated Platinum(Iv) Complex: Crystal Structure and Biological Activity}, journal = {Journal of Organometallic Chemistry}, volume = {799-800}, number = {}, pages = {30-37}, year = {2015} }
RIS	TY - JOUR AU - Abedi A AU - Amani V AU - Safari N AU - Ostad SN AU - Notash B TI - From Proton Transferred to Cyclometalated Platinum(Iv) Complex: Crystal Structure and Biological Activity JO - Journal of Organometallic Chemistry VL - 799-800 IS - SP - 30 EP - 37 PY - 2015 ER -

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