Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Additive Effect of Excimer Laser on Non-Cultured Melanocyte-Keratinocyte Transplantation for the Treatment of Vitiligo: A Clinical Trial in an Iranian Population Publisher Pubmed



Ebadi A1 ; Rad MM1 ; Nazari S1 ; Fesharaki RJ1 ; Ghalamkarpour F1 ; Younespour S2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Skin Research Center, Shahid Beheshti University of Medical Sciences, Shohada-e-tajrish Hospital, Tehran, Iran
  2. 2. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of the European Academy of Dermatology and Venereology Published:2015


Abstract

Background Non-cultured cellular grafting is specified for stable vitiligo treatment as a novel surgical technique, however, the additive effect of excimer laser on melanocytes-keratinocytes transplantation (MKT) have not experienced yet. Objective To assay the additive effect of excimer laser on MKT for the treatment of vitiligo in an Iranian population. Methods and materials In this non-randomized clinical trial, 39 patches were evaluated. Nine patches treated by MKT alone, 10 patches treated by MKT and excimer laser, 10 patches treated with excimer alone and 10 patches left without any treatments as control patches. Results In the patches treated with excimer, the percentage reduction of depigmented area from baseline varied, ranging from 0 to 43.9%. In the nine patches treated with non-cultured MKT, the median percentage reduction of depigmented area from baseline was 15.9%. The median percentage reduction of depigmented area in excimer + MKT was 41.9%.In the untreated patches, the median percentage reduction of depigmented area was 0.1%. After controlling for the effect of 'depigmented area at baseline', significant reductions were observed in depigmented area of the patches treated with combination therapy of excimer and non-cultured MKT in comparison with the other therapies and untreated patches. Conclusion Although pigmentation in our patients was lower than previous reports from Iran and other countries, however, we signified adding excimer to MKT increased the pigmentation rate in treated patches. Further investigations are recommended with longer follow-up and larger series to validate the findings reported here. © 2014 European Academy of Dermatology and Venereology.
Related Docs
1. Hair Follicle As a Source of Pigment-Producing Cells for Treatment of Vitiligo: An Alternative to Epidermis?, Tissue Engineering and Regenerative Medicine (2020)
2. The Effect of Melanocyte Cell Suspension in Jokliks Medium in the Treatment of Stable Resistant Vitiligo: Report of 10 Cases, Journal of Isfahan Medical School (2015)
3. Transplantation of Autologous Epidermal Melanocyte–Keratinocyte Cells Suspension for Cell Therapy of Vitiligo: A Clinical Evaluation and Biometric Assessment, Journal of Cosmetic Dermatology (2022)
4. Combination of Epidermal Keratinocyte–Melanocyte Cells Suspension and Microneedling: Safe Surgical Approach in Vitiligo, Journal of Cosmetic Dermatology (2022)
5. Autologous Melanocyte–Keratinocyte Suspension in Patients With Postburn Leukoderma: Dermabrasion Versus Erbium Yag Laser for Recipient Site Preparation, Journal of Isfahan Medical School (2017)
6. Notable Enhancement of Facial Scarring Following Autologous Melanocyte-Keratinocyte Transplantation and Nuvb Therapy: A Case Report, Journal of Lasers in Medical Sciences (2022)
7. The Efficacy of an Innovative Method of Melanocytes-Keratinocytes Suspension for the Treatment of Stable Vitiligo (A Report of 20 Cases), Journal of Isfahan Medical School (2016)
Experts (# of related papers)
Mohammad Ali Nilforoushzadeh (6)