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Alzheimer's Disease and the Role of Infectious Agents: A Review



Ghannad MS1 ; Hosseini SM1 ; Kazemian H2 ; Gharib A3
Authors
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Authors Affiliations
  1. 1. Research Center for Molecular Medicine, Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Department of Microbiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Physiology and Pharmacology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

Source: Journal of Chemical and Pharmaceutical Sciences Published:2016

Abstract

Alzheimer's disease (AD) is considered as a neurodegenerative disease in elderly people. Several hypotheses have been proposed in the development of AD. Infection with pathogenic agents such as viruses can be one of these hypotheses. In this review, data on the possible association between the infectious agents and AD has been collected and summarized. The current study revealed that infectious agents express proteins (pentapeptides or more) with obvious homology to beta-amyloid protein (Aβ) and amyloid precursor protein (APP). Hitherto, infection with pathogens such as herpes simplex virus type 1 (HSV-1), picornavirus, Borna disease virus, cytomegalovirus (CMV), Epstein Barr virus (EBV), or human herpes virus 6 (HHV-6) have been reported to be associated with the pathophysiology of AD. These researchers suggest that some infectious agents, may contribute to the pathogenesis of AD. Therefore, with the prevention and treatment of such infectious agents the sanitation authorities can decrease the risk of AD.
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