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Neuroendocrine Carcinoma of the Tongue Publisher Pubmed



Esmati E1 ; Babaei M1 ; Matini A2 ; Ashtiani MSM4 ; Hamed EA3 ; Nosrati H1 ; Razi F4 ; Ganjalikhani M4
Authors
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Authors Affiliations
  1. 1. Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Keshavarz Blvd., Tehran, Iran
  2. 2. Department of Pathology, Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Department of Radiation Oncology, Mahdieh Hospital, Hamedan, Iran
  4. 4. Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Cancer Research and Therapeutics Published:2015


Abstract

Neuroendocrine carcinoma usually originates from lung. Few data exist in the literature regarding neuroendocrine carcinoma of the tongue. Patient data including history, surgical procedure, histology, and radiology investigations were collected and summarized. A 40-year-old woman was referred after partial glossectomy. Squamous mucosa with neoplasm and cells with round nuclei and light cytoplasm was reported in the tongue biopsy. Immunohistochemistry (IHC) staining was positive for cytokeratin, neuron specific enolase, synaptophysin and chromogranin and negative for leukocyte common antigen. This case showed a high proliferative activity (Ki-67 labeling index were 60%). These IHC findings were in favor of poorly differentiated neuroendocrine carcinoma. After surgery, she received chemotherapy and chemoradiation. The diagnosis of neuroendocrine tumors in the present case is based on immunohistochemical markers and cellular shapes. Postoperative chemoradiotherapy is a critical element of therapy for head and neck high-grade neuroendocrine carcinomas, our patient received this treatment after surgery.