Fungal Keratitis Caused by Pseudallescheria Boydii: Clinical and Mycological Characteristics Publisher



Izadi A¹ ; Soleimani M² ; Dos Santos CO³ ; Tehupeiorykooreman MC³ ; Daie Ghazvini R¹ ; Hashemi SJ¹ ; Gramishoar M¹ ; Aminizadeh M² ; Abedinifar Z⁴ ; Verweij PE³ ; Khodavaisy S¹ Show Affiliations
Source: Journal of Ophthalmic Inflammation and Infection Published:2021

Abstract

Background: Pseudallescheria keratitis is rare but important type of fungal keratitis because of the inherently resistance of the organism to many existing antifungal agents. Methods: Slit-lamp and confocal microscopy were used for clinical examinations. Fungal isolates were identified based on morphological characteristics and DNA sequence of the internal transcribed spacer region (ITS). In vitro antifungal susceptibility testing for fungal isolates was performed according to the Clinical and Laboratory Standards Institute (CLSI, M38-A2). Result: All patients had a history of ocular trauma. In clinical examination hypopion were seen in three patients. The main antifungal medications were topical voriconazole. After treatment the visual acuity of all patients improved in 2–3 weeks. Conclusion: All four patients of Pseudallescheria keratitis had similar clinical features. Accurate and rapid identification of species should be helpful in treating p. boydii keratitis. © 2021, The Author(s).