Regio- and Stereoselective Synthesis of Dispiropyrrolidineoxindole Derivatives by Using Classical and Microwave Conditions, and Molecular Docking Studies of Them As Potential Cyclin Dependent Kinases (Cdk5) Inhibitors

Regio- and Stereoselective Synthesis of Dispiropyrrolidineoxindole Derivatives by Using Classical and Microwave Conditions, and Molecular Docking Studies of Them As Potential Cyclin Dependent Kinases (Cdk5) Inhibitors Publisher

Moghaddam FM¹ ; Hosseinzadeh N¹ ; Fazli H¹ ; Sadredini S¹ ; Foroumadi A²

Show Affiliations

1. Department of Chemistry, Laboratory of Organic Synthesis and Natural Products, Sharif University of Technology, Tehran, Iran
2. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Polycyclic Aromatic Compounds Published:2023

Abstract

A Solvent-free microwave-assisted green approach has been presented the synthesis of dispiropyrrolidineoxindole compounds with regio- and stereoselectivity and the excellent yields in short reaction times. A comparative study of the synthesis of dispiropyrrolidineoxindole derivatives by conventional heating and microwave condition has been described by the cycloaddition of azomethine ylides generated from sarcosine and isatin with the dipolarophile aurones. Molecular docking studies were carried out to explore the synthesized bispirooxindoles as inhibitors of CDK5. One of these compounds exhibited excellent binding affinity for cyclin dependent kinases (CDK5). Also, the structures were established by spectroscopic techniques as well as single crystal X-ray analysis. © 2022 Taylor & Francis Group, LLC.

Experts (# of related papers)

Mohammad Mahdavi (1)

Style	Citing Format
MLA	Moghaddam FM, et al.. "Regio- and Stereoselective Synthesis of Dispiropyrrolidineoxindole Derivatives by Using Classical and Microwave Conditions, and Molecular Docking Studies of Them As Potential Cyclin Dependent Kinases (Cdk5) Inhibitors." Polycyclic Aromatic Compounds, vol. 43, no. 8, 2023, pp. 6898-6910.
APA	Moghaddam FM, Hosseinzadeh N, Fazli H, Sadredini S, Foroumadi A (2023). Regio- and Stereoselective Synthesis of Dispiropyrrolidineoxindole Derivatives by Using Classical and Microwave Conditions, and Molecular Docking Studies of Them As Potential Cyclin Dependent Kinases (Cdk5) Inhibitors. Polycyclic Aromatic Compounds, 43(8), 6898-6910.
Chicago	Moghaddam FM, Hosseinzadeh N, Fazli H, Sadredini S, Foroumadi A. "Regio- and Stereoselective Synthesis of Dispiropyrrolidineoxindole Derivatives by Using Classical and Microwave Conditions, and Molecular Docking Studies of Them As Potential Cyclin Dependent Kinases (Cdk5) Inhibitors." Polycyclic Aromatic Compounds 43, no. 8 (2023): 6898-6910.
Harvard	Moghaddam FM et al. (2023) 'Regio- and Stereoselective Synthesis of Dispiropyrrolidineoxindole Derivatives by Using Classical and Microwave Conditions, and Molecular Docking Studies of Them As Potential Cyclin Dependent Kinases (Cdk5) Inhibitors', Polycyclic Aromatic Compounds, 43(8), pp. 6898-6910.
Vancouver	Moghaddam FM, Hosseinzadeh N, Fazli H, Sadredini S, Foroumadi A. Regio- and Stereoselective Synthesis of Dispiropyrrolidineoxindole Derivatives by Using Classical and Microwave Conditions, and Molecular Docking Studies of Them As Potential Cyclin Dependent Kinases (Cdk5) Inhibitors. Polycyclic Aromatic Compounds. 2023;43(8):6898-6910.
BibTex	@article{ author = {Moghaddam FM and Hosseinzadeh N and Fazli H and Sadredini S and Foroumadi A}, title = {Regio- and Stereoselective Synthesis of Dispiropyrrolidineoxindole Derivatives by Using Classical and Microwave Conditions, and Molecular Docking Studies of Them As Potential Cyclin Dependent Kinases (Cdk5) Inhibitors}, journal = {Polycyclic Aromatic Compounds}, volume = {43}, number = {8}, pages = {6898-6910}, year = {2023} }
RIS	TY - JOUR AU - Moghaddam FM AU - Hosseinzadeh N AU - Fazli H AU - Sadredini S AU - Foroumadi A TI - Regio- and Stereoselective Synthesis of Dispiropyrrolidineoxindole Derivatives by Using Classical and Microwave Conditions, and Molecular Docking Studies of Them As Potential Cyclin Dependent Kinases (Cdk5) Inhibitors JO - Polycyclic Aromatic Compounds VL - 43 IS - 8 SP - 6898 EP - 6910 PY - 2023 ER -

Style

Citing Format

MLA

Moghaddam FM, et al.. "Regio- and Stereoselective Synthesis of Dispiropyrrolidineoxindole Derivatives by Using Classical and Microwave Conditions, and Molecular Docking Studies of Them As Potential Cyclin Dependent Kinases (Cdk5) Inhibitors." Polycyclic Aromatic Compounds, vol. 43, no. 8, 2023, pp. 6898-6910.

APA

Moghaddam FM, Hosseinzadeh N, Fazli H, Sadredini S, Foroumadi A (2023). Regio- and Stereoselective Synthesis of Dispiropyrrolidineoxindole Derivatives by Using Classical and Microwave Conditions, and Molecular Docking Studies of Them As Potential Cyclin Dependent Kinases (Cdk5) Inhibitors. Polycyclic Aromatic Compounds, 43(8), 6898-6910.

Chicago

Moghaddam FM, Hosseinzadeh N, Fazli H, Sadredini S, Foroumadi A. "Regio- and Stereoselective Synthesis of Dispiropyrrolidineoxindole Derivatives by Using Classical and Microwave Conditions, and Molecular Docking Studies of Them As Potential Cyclin Dependent Kinases (Cdk5) Inhibitors." Polycyclic Aromatic Compounds 43, no. 8 (2023): 6898-6910.

Harvard

Moghaddam FM et al. (2023) 'Regio- and Stereoselective Synthesis of Dispiropyrrolidineoxindole Derivatives by Using Classical and Microwave Conditions, and Molecular Docking Studies of Them As Potential Cyclin Dependent Kinases (Cdk5) Inhibitors', Polycyclic Aromatic Compounds, 43(8), pp. 6898-6910.

Vancouver

Moghaddam FM, Hosseinzadeh N, Fazli H, Sadredini S, Foroumadi A. Regio- and Stereoselective Synthesis of Dispiropyrrolidineoxindole Derivatives by Using Classical and Microwave Conditions, and Molecular Docking Studies of Them As Potential Cyclin Dependent Kinases (Cdk5) Inhibitors. Polycyclic Aromatic Compounds. 2023;43(8):6898-6910.

BibTex

@article{ author = {Moghaddam FM and Hosseinzadeh N and Fazli H and Sadredini S and Foroumadi A}, title = {Regio- and Stereoselective Synthesis of Dispiropyrrolidineoxindole Derivatives by Using Classical and Microwave Conditions, and Molecular Docking Studies of Them As Potential Cyclin Dependent Kinases (Cdk5) Inhibitors}, journal = {Polycyclic Aromatic Compounds}, volume = {43}, number = {8}, pages = {6898-6910}, year = {2023} }

RIS

TY - JOUR
AU - Moghaddam FM
AU - Hosseinzadeh N
AU - Fazli H
AU - Sadredini S
AU - Foroumadi A
TI - Regio- and Stereoselective Synthesis of Dispiropyrrolidineoxindole Derivatives by Using Classical and Microwave Conditions, and Molecular Docking Studies of Them As Potential Cyclin Dependent Kinases (Cdk5) Inhibitors
JO - Polycyclic Aromatic Compounds
VL - 43
IS - 8
SP - 6898
EP - 6910
PY - 2023
ER -

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