Comparison of Two Dosing Regimens of Intravaginal Misoporostol for Second-Trimester Abortion Publisher



Ghasemi M¹ ; Arbabzadeh T² ; Baradaran Z² ; Sarvi F³ Show Affiliations
Source: Iranian Journal of Obstetrics# Gynecology and Infertility Published:2018

Abstract

Introduction: Globally, the second-trimester abortion accounts for 10-15% of all abortions and is responsible for two-thirds of abortion-related complications. Misoprostol is known as a potent and effective medication for the termination of pregnancy in the second trimester. Several studies with different results were performed in the proper dosage of misoprostol; However, there is no consensus about its proper dosage. This study was performed to compare the efficacy of two doses of vaginal misoprostol for the second trimester abortion. Methods: This randomized clinical trial was conducted among 100 pregnant women who were hospitalized for the second trimester abortion. They were randomly assigned to two groups in the Department of Obstetrics and Gynecology, Ali ibn Abi Talib Hospital, Zahedan, Iran, 2013. Subjects in the first and second groups received vaginal misoprostol at 400 μg given every 3 hours and 600 μg given every 6 hours up to five doses, respectively. Data were collected using a form containing the received dose, abortion interval, and complications. Data analysis was performed using Chi-squared and t-test. P <0.05 was considered statistically significant. Results: The mean age of participants was 58.5 ± 5.5 years old; and all the abortions were successful. In the first group, the total administered dose was significantly lower than the other group (P <0.001). Additionally, in the first group, the complications and abortion intervals were less than the other group; However, there was no significant difference between them (P = 0.108). Conclusion: Both the studied dosages of misoprostol had similar effects and the rate of complication was the same. Nonetheless, the 400mg dose was preferred because of a lower total dose and a shorter abortion interval. © 2018, Mashhad University of Medical Sciences. All rights reserved.