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Effects of Iodine Supplementation During Pregnancy on Pregnant Women and Their Offspring: A Systematic Review and Meta-Analysis of Trials Over the Past 3 Decades Publisher Pubmed



Nazeri P1 ; Shariat M2 ; Azizi F3
Authors
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Authors Affiliations
  1. 1. Family Health Institute, Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Family Health Institute Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: European Journal of Endocrinology Published:2021


Abstract

Objective: The current systematic review aimed to provide comprehensive d ata on the effects of iodine supplementation in pregnancy and investigate its potential bene fits on infant growth parameters and neurocognitive development using meta-analysis. Methods: A systematic review was conducted on trials published from Jan uary 1989 to December 2019 by searching MEDLINE, Web of Science, the Cochrane Library, Scopus, and Goog le Scholar. For most maternal and neonatal outcomes, a narrative synthesis of the data was performed. For birth anthropometric measurements and infant neurocognitive outcomes, the pooled standardized mean differences (SMDs) with 95% CIs were estimated using fixed/random effect models. Results: Fourteen trials were eligible for inclusion in the systematic review, of which five trials were included in the meta-analysis. Although the findings of different thyroid paramet ers are inconclusive, more consistent evidence showed that iodine supplementation could prevent the increase i n thyroglobulin concentration during pregnancy. In the meta-analysis, no differences were found in weight (-0.11 (95% CI: -0.23 to 0.01)), length (-0.06 (95% CI: -0.21 to 0.09)), and head circumference (0.26 (95% CI: -0.35 to 0.88)) at birth, or in cognitive (0.07 (95% CI: -0.07 to 0.20)), language (0.06 (95% CI: -0.22 to 0.35)), and motor (0.07 (95% CI: -0.06 to 0.21)) development during the first 2 years of life in infants between the iodine-supplemented and control gro ups. Conclusion: Iodine supplementation during pregnancy can improve the iodine status in pregnant women and their offspring; however, according to our meta-analysis, there was no evidence of improved growth or neurodevelopmental outcomes in infants of iodine-supplemented mothers. © 2021 European Society of Endocrinology.
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