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Facile Access to New Pyrido[2,3-D]Pyrimidine Derivatives Publisher Pubmed



Ghaedi A1 ; Bardajee GR1 ; Mirshokrayi A1 ; Mahdavi M2 ; Akbarzadeh T3, 4
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Payame Noor University (PNU), P.O. BOX 19395-3697, Tehran, Iran
  2. 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Molecular Diversity Published:2019


Abstract

Abstract: In this report, a facile, operationally, simple and highly efficient one-pot coupling of 2,6-diaminopyrimidin-4(3H)-one and ethyl-2,4-dioxo-4-phenylbutanoate derivatives is reported. This method afforded a novel series of ethyl-2-amino-3,4-dihydro-4-oxo-5-phenyl pyrido[2,3-d] pyrimidine-7-carboxylate heterocycle derivatives in high yields under refluxing AcOH. Graphical abstract: [Figure not available: see fulltext.]. © 2018, Springer International Publishing AG, part of Springer Nature.