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Effect of Single-Dose Methotrexate Treatment on Ovarian Reserve in Women With Ectopic Pregnancy Undergoing Infertility Treatment: A Single-Center Experience Publisher



Shirazi M1, 2 ; Pooransari P3 ; Hajiha N2 ; Shaker Z1 ; Ghazi M2 ; Tanha FD1 ; Yekta BG4, 5 ; Ghaemi M1, 6
Authors
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Authors Affiliations
  1. 1. Maternal, Fetal and Neonatal Research Center, Tehran, Iran
  2. 2. Breast Feeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Young Researchers and Ethics Club, Tehran Medical Science Branch, Islamic Azad University, Tehran, Iran
  5. 5. Herbal Pharmacology Research Center, Tehran Medical Science Branch, Islamic Azad University, Tehran, Iran
  6. 6. Kamali Hospital, Alborz University of Medical Sciences, Karaj, Iran

Source: International Journal of Fertility and Sterility Published:2020


Abstract

Background: The aim of this study was evaluation of the impact of single-dose methotrexate (MTX) treatment on ovarian reserve in women with ectopic pregnancy (EP) undergoing infertility treatment in Iranian population. Materials and Methods: This prospective cohort study was done between March 2015 and March 2017 in Tehran General Women Hospital, Tehran, Iran. We enrolled 20 patients with EP who conceived during infertility treatment and received a single-dose MTX (50 mg/m2) intramuscularly. Serum anti-Mullerian hormone (AMH), 17 beta-estra-diol (E2), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and antral follicle count (AFC) on transvaginal ultrasonography, were evaluated before and 8 weeks after administration of MTX. Results: AMH did not significantly vary after the administration of MTX, compared to before treatment value (P=0.36). FSH, E2 and AFC changes were not statistically significant, while increment of LH was significant (P=0.02). Conclusion: Results indicated that single-dose MTX treatment did not reduce ovarian reserve in women with EP. Further randomized controlled clinical trial studies with larger sample sizes, by using multiple dosages of MTX, and with long-term follow up are suggested to be done. © 2020, Royan Institute (ACECR). All rights reserved.