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Burkitt's Lymphoma Presenting As Acute Dacryocystitis in a 14-Year-Old Male With Ataxia Telangiectasia: A Case Report and Review of the Literature Publisher



Khannejad S1 ; Mansourian S2 ; Aghajani A2 ; Nozarian Z3 ; Rafizadeh SM2
Authors
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Authors Affiliations
  1. 1. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Oculo-facial Plastic and Reconstructive Surgery, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pathology, Farabi Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: American Journal of Ophthalmology Case Reports Published:2025


Abstract

Purpose: This report describes an atypical presentation of a case of Burkitt lymphoma in a pediatric patient with ataxia telangiectasia. Main observations: A 14-year-old boy with a history of AT was referred to our hospital with lower eyelid swelling and medial canthus abscess. On physical examination, movement of the left eye was limited in downgaze and adduction. Two mm proptosis was observed on the left side. Snellen's Visual acuity in the left eye was 8/20. The rest of the examination was normal. Magnetic resonance imaging (MRI) was performed and showed an infiltrative mass in the inferior of the left orbit, left ethmoidal sinus, and maxillary sinus. The patient subsequently underwent an incisional biopsy. The biopsy specimen was sent for histopathologic evaluation. Histopathology was significant for atypical monotonous cell infiltrations in the fibroconnective tissue and the presence of pleomorphic, irregularly shaped nuclei with multiple mitoses. Immunohistochemistry (IHC) findings were consistent with Burkitt's lymphoma, and the patient was referred to the oncology department for chemotherapy and appropriate treatment. Conclusion: and Significance Orbital and lacrimal duct involvement is a rare presentation of Burkitt lymphoma especially in the pediatric population. In the new-onset nasolacrimal duct obstruction (NLDO) in a child or teenager, the differential diagnosis should include malignancies, especially leukemia/lymphoma infiltrations. © 2025 The Authors
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