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Diagnostic Efficacy of Serum Micrornas in Predicting Pathology of Retroperitoneal Lymph Node Dissection in Patients With Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis Publisher Pubmed



Kardoust Parizi M1, 2 ; Singla N3 ; Daneshmand S4 ; Heidenreich A1, 5 ; Bagrodia A6 ; Margulis V7 ; Matsukawa A1, 8 ; Tsuboi I1, 9 ; Shariat SF1, 7, 10, 11, 12, 13, 14
Authors
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Authors Affiliations
  1. 1. Department of Urology, Comprehensive Cancer Center, Vienna General Hospital, Medical University of Vienna, Wahringer Gurtel 18-20, Vienna, 1090, Austria
  2. 2. Department of Urology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, United States
  4. 4. Department of Urology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, United States
  5. 5. Department of Urology, Uro-Oncology, Robot-Assisted and Specialized Urologic Surgery, University Hospital Cologne, Cologne, Germany
  6. 6. Department of Urology, University of California San Diego, San Diego, CA, United States
  7. 7. Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, United States
  8. 8. Department of Urology, Jikei University School of Medicine, Tokyo, Japan
  9. 9. Department of Urology, Faculty of Medicine, Shimane University, Shimane, Japan
  10. 10. Departments of Urology, Weill Cornell Medical College, New York, NY, United States
  11. 11. Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria
  12. 12. Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic
  13. 13. Division of Urology, Department of Special Surgery, The University of Jordan, Amman, Jordan
  14. 14. Research Center for Evidence Medicine, Urology Department, Tabriz University of Medical Sciences, Tabriz, Iran

Source: World Journal of Urology Published:2025


Abstract

Purpose: To evaluate the diagnostic efficacy of serum microRNAs in predicting pathologic findings of retroperitoneal lymph node dissection (RPLND) in patients with testicular germ cell tumors (TGCT). Methods: PUBMED, SCOPUS, and Cochrane Library were searched in August 2024 to identify eligible studies according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines. Results: Nine studies comprising 603 patients were selected in this review. The pooled sensitivity, specificity, and diagnostic odds ratio (DOR) of microRNA-371a-3p for predicting viable tumor other than pure teratoma in RPLND specimen were 0.76 (95% CI 0.49–0.90), 0.97 (95% CI 0.81–0.99) and 31.75 (95% CI 9.24–109.10), respectively. The pooled sensitivity for primary and post-chemotherapy RPLND (PC-RPLND), were 0.77 (95% CI 0.47–0.93) and 0.73 (95% CI 0.28–0.95), respectively. The pooled specificity for primary and PC-RPLND were 0.92 (95% CI 0.72–0.98) and 0.99 (95% CI 0.62–1.00), respectively. The pooled DOR for primary and PC-RPLND were 13.86 (95% CI 2.97–64.79) and 64.11 (95% CI 13.09–313.98), respectively. The major limitation is the lack of standardization of miR371 testing. Conclusion: miR-371a-3p is a relatively sensitive and highly specific marker for predicting viable tumors in RPLND pathologic findings. The DOR was particularly significant for patients who underwent PC-RPLND. While serum microRNAs may be useful in distinguishing viable germ cell tumors from necrosis, fibrosis, and teratomas, their ability to differentiate teratomas from necrosis is limited. Well-designed prospective studies are essential to enhance our understanding of the predictive performance of microRNAs. © The Author(s) 2025.
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