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Early Phototherapy at Lower Total Serum Bilirubin Can Decrease Auditory Neuropathy Disorder Publisher



Esmaeilnia T1 ; Sagheb S1 ; Sepidarkish M2 ; Mohseni SO3 ; Moeinafshar A4 ; Karimiyazdi A5 ; Shariat M6
Authors
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Authors Affiliations
  1. 1. Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, Iran
  3. 3. School of Molecular Sciences, Arizona State University, Tempe, United States
  4. 4. Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Otorhinolaringology Research Center, Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Breast Feeding Research Center, Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Pediatrics Published:2019


Abstract

Background: Neurologic dysfunctions, specifically hearing impairments due to hyperbilirubinemia are ranked among the main concerns in medicine. Objectives: This study evaluates the prevalence of acute auditory neuropathy (AN) disorders in term neonates with mild to moderate hyperbilirubinemia and low bilirubin-induced neurological dysfunction (BIND) score and the roll of early treatment on reducing their incidence. Methods: Fifty one term jaundice neonates with normal newborn exam and total serum bilirubin (TSB) ≥ 15 mg/dL after the third day of birth with normal otoacoustic emission (OAE) test were enrolled. The BIND score assessment for severity of neurologic dysfunction was done. Neonates with low BIND score were divided into two groups based on their TSB levels at the time of admission (15-18 mg/dL: Mild-moderate hyperbilirubinemia and ≥ 19 mg/dL: Severe hyperbilirubinemia). ABR was performed within the first 12 hours of their admission and the second ABR was performed before discharge. Results: The 30.60% of neonates with TSB < 19 mg/dl had abnormal ABR. Latency of V, III waves and interpeak interval latency of I-III, I-V waves were detected. Mean latency of wave V and I-V interpeak latency after phototherapy were significantly decreased compared to pre-treatment (P < 0.001). Conclusions: With the prevalence of auditory neuropathy (AN) at lower TSB concentrations (that have traditionally been considered safe) it can be concluded that more attention should be given to this group despite the absence of neurologic signs, and it also shows the sensitivity of early phototherapy to lower bilirubin level. © 2019, Author(s).