Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluation of Ki-67 Staining Index and Braf Mutation in Women Diagnosed With Advanced Endometriosis Publisher



Jalaeefar A1 ; Eslami B2 ; Bahar M3 ; Hosseini R4 ; Sharifi A5 ; Rakhshani N6 ; Moini A2, 4, 7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Breast Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Familial and Hereditary Cancers Institute, Tehran, Iran
  4. 4. Department of Gynecology and Obstetrics, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Gastrointestinal and Liver Disease Research Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

Source: Journal of Endometriosis and Pelvic Pain Disorders Published:2023


Abstract

Introduction: Recent studies have proposed that advanced endometriosis might harbor histopathological, molecular, and genetic properties of malignant lesion. Thus we aimed to investigate the presence of Ki-67 staining index (KSI) and BRAF mutation in patients with and without recurrent endometriosis of stage III and IV. Materials and methods: Cross sectional study on 50 consecutive patients with endometriosis of stage III and IV was performed. Tissue specimens collected during laparoscopic surgery were used for the evaluation of presence of KSI and BRAF mutation. Also, serum levels of tumor markers including CA-125, CA19-9, AMH and αFP were gathered. Results: The mean ± SD of KSI was 12.18 ± 16.58. Forty-one out of 50 (82%) patients had a non-recurrent disease. KSI ⩾ 10% was found in 20 patients (40%). Furthermore, 29 patients (58%) and 13 patients (26%) had high levels of CA-125 and CA19-9, respectively. No evidence of significant correlation was observed between the KSI and CA-125 and CA19-9 (all p values > 0.05). However, a positive correlation was observed between CA-125 and CA19-9 (r = 0.55, p-value = 0.02). KSI level was insignificantly lower in recurrent patients compared with non-recurrent patients (9.78 ± 6.24 vs 12.71 ± 18.09, p-value = 0.33). Other tumor markers did not show any statistically significant difference (all p values > 0.05). None of the participants had BRAF V600E mutation. Conclusion: Endometriosis manifests malignant behavioral of rapid proliferation but the exact genetic alteration causing this phenomenon is not understood. © The Author(s) 2023.
Related Docs
1. Association of Vascular Endothelial Growth Factor (Vegf) Gene Polymorphisms and Expression With the Risk of Endometriosis: A Case–Control Study, Molecular Biology Reports (2019)
Experts (# of related papers)
Mahsa Mohamad Amoli (1)