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Depression Is Associated With Downregulation of Ips-1 in Chronic Hbv-Infected Patients in a Sex-Dependent Manner Publisher Pubmed



Safariarababadi M1 ; Modarressi MH1, 2 ; Sheikhfatholahi M3, 4 ; Khaleghinia M5 ; Arababadi MK3, 6
Authors
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Authors Affiliations
  1. 1. Department of Genetic, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  4. 4. Department of Epidemiology and Biostatistics, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  5. 5. Department of Infectious Diseases, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  6. 6. Department of Laboratory Sciences, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Source: NeuroImmunoModulation Published:2021


Abstract

Background: Depression and anxiety can modulate immune-related molecule expressions. The chronic HBV-infected (CHB) patients suffer from inappropriate immune responses. Additionally, psychological disorders are prevalent among the patients. Thus, depression and anxiety may alter immune-related molecule expression. This study aimed to examine IPS-1 and RIP1 mRNA levels in CHB patients suffering from various degrees of anxiety and depression. Methods: Sixty patients with CHB participated in this research and completed standard questionnaires to evaluate depression and anxiety. The expression levels of IPS-1 and RIP1 were examined using real-time PCR techniques. Results: The result revealed that although the expression of IPS-1 and RIP1 did not change in the CHB patients with various ranges of depression and anxiety, IPS-1 was significantly decreased in the male CHB patients who suffered from mild, moderate, and severe depression when compared to the patients with no depression. Conclusion: So, it was hypothesized that depression may be associated with alteration in the expression of IPS-1 in a sex-dependent manner. In other words, it appears that the male CHB patients are at risk of depression-related alteration in immune-related gene expression. © 2021 S. Karger AG. All rights reserved.
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1. Up-Regulation of Rip1 and Ips-1 in Chronic Hbv Infected Patients, Genetics and Molecular Biology (2019)
Experts (# of related papers)
Mohammad Hossein Modarressi (1)