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Inflammatory Biomarkers of Neutrophil-To-Lymphocyte and Platelet-To-Lymphocyte Ratios in 563 Severe Osa Patients Before and After Surgery Publisher Pubmed



Lin CW1 ; Lin PW2, 3, 4 ; Chiu LW1 ; Chai HT5 ; Chang CT6 ; Friedman M7, 8 ; Salapatas AM8 ; Rahaviezabadi S9 ; Lin HC3, 4, 6, 10
Authors
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Authors Affiliations
  1. 1. Department of Education, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
  2. 2. Division of Glaucoma, Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
  3. 3. College of Medicine, Chang Gung University, Taoyuan, Taiwan
  4. 4. Sleep Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
  5. 5. Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
  6. 6. Department of Business Management, Institute of Healthcare Management, Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan
  7. 7. Department of Otolaryngology, Division of Sleep Surgery, Rush University Medical Center, Chicago, IL, United States
  8. 8. Department of Otolaryngology, Advanced Center for Specialty Care, Advocate Illinois Masonic Medical Center, Chicago, IL, United States
  9. 9. Otorhinolaryngology Head and Neck Surgery Department, Otorhinolaryngology Research Center, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Otolaryngology, Robotic Surgery Center and Center for Quality Management, Kaohsiung Chang Gung Memorial Hospital, 123, Ta-Pei Rd., Niao-Sung District, Kaohsiung, 833, Taiwan

Source: Journal of Otolaryngology - Head and Neck Surgery Published:2023


Abstract

Background: Evidence has proved that high neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were risk factors for cardiovascular comorbidities. The alterations of NLR and PLR following obstructive sleep apnea (OSA) treatment were under studied and thus should be investigated. This study aimed to evaluate the changes of inflammatory biomarkers including NLR and PLR in severe OSA patients after surgical interventions of the upper airway, and their relationships with improvements in polysomnographic (PSG) parameters. Methods: This retrospective cohort study included 563 consecutive severe OSA patients at a tertiary academic medical center who received OSA surgery, as well as underwent pre- and post-operative polysomnographic (PSG) examinations and blood tests. The changes of major PSG estimates, NLR, and PLR before and at least 3 months after OSA surgery were analyzed using paired t-tests with subgroup analyses. Pearson’s correlations were performed to discover which PSG parameter contributed to the improvement of the values. Results: After OSA surgery, the major PSG estimates, NLR and PLR dropped significantly in the overall population. In those with a higher preoperative NLR (pre-operative NLR≧3) and PLR (pre-operative PLR≧150), the mean (SD) difference of NLR (− 0.8 [1.6], 95% CI − 1.5 to − 0.2) and PLR (− 41.6 [40], 95% CI − 52.8 to − 30.5) were even more substantial. The changes of the “apnea, longest (r = 0.298, P =.037)” and “hypopnea, longest (r = 0.321, P =.026)” were found significantly related to the improvement of PLR. Conclusion: NLR and PLR did significantly drop in severe OSA patients following OSA surgery, and this could be related to the alterations of sleep indices. The findings could possess clinical importance for severe OSA patients after OSA surgeries in reducing possible OSA-associated cardiovascular comorbidities. © 2023, The Author(s).
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