Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Carbon Nanotubes Provide Longer Lasting Gastroprotective Effects for Anandamide in Stress-Induced Gastric Ulcer in Rat



Hassanzadeh P1 ; Arbabi E2 ; Atyabi F1 ; Dinarvand R1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Teheran, Iran

Source: Physiology and Pharmacology (Iran) Published:2018

Abstract

Introduction: Anandamide (AEA) has shown a wide spectrum of pharmacological activities including the effects against the peptic ulcer, meanwhile, the poor solubility or short half-life may negatively affect the effectiveness of this valuable cannabinoid. Based on the superior properties of carbon nanotubes (CNTs) for controlled drug delivery, we aimed to prepare AEA-CNTs complex and evaluate its therapeutic potential in an experimental model of gastric ulcer. Methods: Amino-functionalized multi-walled CNTs-AEA (MWCNTs-AEA) complex was prepared using COOH-MWCNTs and then characterized by Fourier transform infrared spectroscopy and transmission electron microscopy. Gastric ulcer was induced by water immersion and restrain stress (WRS) for 3.5 and 6 h in rats and the gastric lesion and oxidative stress were evaluated. Results: AEA at higher doses reduced the gastric ulcer area and malondialdehyde content and elevated glutathione level and superoxide dismutase and catalase activities after 3.5-h WRS but it was ineffective after 6-h WRS. MWCNTs-AEA complex showed therapeutic effects after both 3.5- and 6-h WRS. Conclusion: Aminated MWCNTs are suitable carriers for AEA as they provide longer lasting effects for this cannabinoid. The antioxidant mechanism may be involved in the gastroprotective effects of MWCNTs-AEA complex. © 2018, Iranian Society of Physiology and Pharmacology. All rights reserved.
Related Docs
View other Related Docs
1. Carbon Nanotube-Anandamide Complex Exhibits Sustained Protective Effects in an in Vitro Model of Stroke, Physiology and Pharmacology (2016)
2. Nerve Growth Factor-Carbon Nanotube Complex Exerts Prolonged Protective Effects in an in Vitro Model of Ischemic Stroke, Life Sciences (2017)
3. Application of Carbon Nanotubes for Controlled Release of Growth Factors or Endocannabinoids: A Breakthrough in Biomedicine, Biomedical Reviews (2016)
4. Application of Carbon Nanotubes As the Carriers of the Cannabinoid, 2-Arachidonoylglycerol: Towards a Novel Treatment Strategy in Colitis, Life Sciences (2017)
5. Carbon Nanotubes Prolong the Regulatory Action of Nerve Growth Factor on the Endocannabinoid Signaling, Physiology and Pharmacology (2015)
6. Application of Nanostructured Lipid Carriers: The Prolonged Protective Effects for Sesamol in in Vitro and in Vivo Models of Ischemic Stroke Via Activation of Pi3k Signalling Pathway, DARU# Journal of Pharmaceutical Sciences (2017)
7. Ferulic Acid-Loaded Nanostructured Lipid Carriers: A Promising Nanoformulation Against the Ischemic Neural Injuries, Life Sciences (2018)
8. Towards the Quantum-Enabled Technologies for Development of Drugs or Delivery Systems, Journal of Controlled Release (2020)
Experts (# of related papers)
View all Related Experts
Fatemeh Atyabi (14)
Rassoul Dinarvand (14)
Other Related Docs
9. Application of Modelling and Nanotechnology-Based Approaches: The Emergence of Breakthroughs in Theranostics of Central Nervous System Disorders, Life Sciences (2017)
10. Resveratrol: More Than a Phytochemical, Biomedical Reviews (2015)
11. Ferulic Acid, a Phenolic Compound With Therapeutic Effects in Neuropsychiatric Disorders, Stimulates the Production of Nerve Growth Factor and Endocannabinoids in Rat Brain, Physiology and Pharmacology (Iran) (2017)
12. Ignoring the Modeling Approaches: Towards the Shadowy Paths in Nanomedicine, Journal of Controlled Release (2018)
13. The Significance of Artificial Intelligence in Drug Delivery System Design, Advanced Drug Delivery Reviews (2019)
14. Linkers: The Key Elements for the Creation of Efficient Nanotherapeutics, Journal of Controlled Release (2018)
15. Carbon Nanotubes Part Ii: A Remarkable Carrier for Drug and Gene Delivery, Expert Opinion on Drug Delivery (2015)
16. The Significance of Bioengineered Nanoplatforms Against Sars-Cov-2: From Detection to Genome Editing, Life Sciences (2021)
17. Neuroprotective Effects of Three Different Sizes Nanochelating Based Nano Complexes in Mpp(+) Induced Neurotoxicity, Apoptosis (2015)
18. The Endocannabinoid System and Ngf Are Involved in the Mechanism of Action of Resveratrol: A Multi-Target Nutraceutical With Therapeutic Potential in Neuropsychiatric Disorders, Psychopharmacology (2016)
19. Creation of Nanorobots: Both State-Of-The-Science and State-Of-The-Art, Biomedical Reviews (2016)