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The Hormone-Sensitive Lipase C-60G Polymorphism Is Correlated With Recurrent Spontaneous Abortion in Women With Polycystic Ovary Syndrome Publisher



Eivazi S1 ; Kheirollahi A2 ; Vatannejad A2 ; Borumandnia N3 ; Habibi B4 ; Shapourizadeh S5 ; Fouani FZ6 ; Ansaripour S7 ; Eivazi S1 ; Zandieh Z8
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Authors Affiliations
  1. 1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  3. 3. Urology and Nephrology Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biology, Faculty of Postgraduate, Borujerd Branch, Islamic Azad University, Borujerd, Iran
  5. 5. School of Mohadeseh, Shahriyar Education Office, Ministry of Education, Tehran, Iran
  6. 6. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
  8. 8. Shahid Akbar Abadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences, Tehran, Iran

Source: Gene Reports Published:2023


Abstract

Objective(s): Disrupted lipid metabolism has been associated with the development of polycystic ovary syndrome (PCOS) in women of reproductive age. Hormone-sensitive lipase (HSL) is an intracellular lipase that has a crucial role in normal lipid metabolism. This study aimed to assess the frequency of C-60G polymorphism of HSL in healthy women and PCOS women, and its correlation with infertility and recurrent spontaneous abortion (RSA) in PCOS patients. Study design: A total of 324 PCOS patients (including 199 infertile patients and 125 patients with a history of RSA and 144 healthy controls) were enrolled in this study. Biochemical parameters were measured, and the genotypes of C-60G polymorphism of the HSL gene were determined using PCR-restriction fragment length polymorphism (RFLP) techniques. Results: There was no significant difference in the genotype and allele frequencies of C-60G polymorphism between PCOS, PCOS-infertile woman, and non-PCOS subjects. However, a higher percentage of combined variants (CG + GG) and CG genotypes, as well as G allele was found in the PCOS-RSA group in comparison with non-PCOS women. The presence of the G allele conferred a 2.4-fold risk for RSA in women with PCOS (OR: 2.4, 95 % CI [1.22–4.70], P = 0.011). Furthermore, a significant correlation between CG or GG genotype of HSL and the level of free testosterone was observed. Conclusion: According to the obtained results, the C-60G polymorphism in the HSL promoter was associated with PCOS-related RSA, possibly through increasing the level of free testosterone. Therefore, the rs34845087 polymorphism may be a promising prognostic biomarker for RSA in women with PCOS. © 2023
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