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Synthesis of Chromene-Fused Heterocycles by the Intramolecular–Diels–Alder Reaction: An Overview Publisher



Sheykhi S1 ; Pedrood K2 ; Amanlou M1 ; Larijani B2 ; Mahdavi M2
Authors
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Authors Affiliations
  1. 1. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Tetrahedron Published:2021


Abstract

The formation of several polycyclic compounds via the intramolecular–Diels–Alder reaction is reviewed. Furthermore, a thorough explanation has been given about the intramolecular–Diels–Alder reaction mechanism and the recent reactions carried out in this realm with O-propargyl salicylaldehydes as the starting material. Additionally, the strategies for the synthesis of chromene-fused heterocycles have been introduced and compared. The primary aim of this review is to provide up-to-date information about the application of the intramolecular–Diels–Alder reaction in the synthesis of a wide range of chromene-fused heterocycles in the recent chemical literature. © 2021