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Spectrofluorimetric Method for Determination of Bupropion in Pharmaceutical Dosage Forms; [Methode De Determination Spectrofluorimetrique Du Bupropion Dans Les Formulations Pharmaceutiques] Publisher Pubmed



Souri E1 ; Rahmatpoor S1 ; Barazandeh Tehrani M1
Authors
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Authors Affiliations
  1. 1. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14155-6451, Iran

Source: Annales Pharmaceutiques Francaises Published:2019


Abstract

Objective: Bupropion is a noradrenaline and dopamine reuptake inhibitor which is used as an antidepressant drug. Few HPLC and spectrophotometric methods have been reported before for the determination of bupropion. Most of the previous methods reported for determination of bupropion in pharmaceutical dosage forms are somehow dangerous to health and environment because of using organic solvents. Method: In the present method bupropion was determined in pharmaceutical dosage forms by spectrofluorimetry after ion-pair complex formation with eosin Y. The ion-pair complex formation was optimized for reagent amount, buffer pH and time. Result: The developed method was linear over the range of 3–120 μg mL−1 with an acceptable precision (CV < 1.5%) and accuracy (Error < 1%). Conclusion: The present method is applicable for determination of bupropion in pharmaceutical dosage forms for routine quality control analysis. © 2019